Fraser A, Ebrahim S, Davey Smith G, Lawlor D A
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK.
J Epidemiol Community Health. 2008 Jan;62(1):48-53. doi: 10.1136/jech.2006.053181.
To examine the separate associations of leg length, a biomarker of prepubertal exposures and growth, and trunk length with adult levels of liver enzymes: alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate transaminase (AST) and alkaline phosphatase (ALP).
A cross-sectional analysis of baseline data from the British Women's Health and Heart Study, a random sample of British women aged 60-79 years.
Leg length was inversely associated with age-adjusted levels of ALT, GGT and ALP. These associations remained when controlling for childhood and adulthood social class, physical activity, smoking, alcohol consumption, waist-to-hip ratio and trunk length. Trunk length was positively associated with ALT and inversely associated with ALP and the associations remained when adjusting for covariables.
Adult liver function is affected by early life environmental exposures as reflected in leg length, and this may suggest common childhood influences on liver development and adult risk of diabetes and coronary heart disease. Further studies with detailed measures of early life exposures relevant to leg length would be valuable in identifying any specific exposures contributing to adult liver function and cardiovascular disease.
探讨腿长（青春期前暴露和生长的生物标志物）和躯干长度与成人肝脏酶水平（丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）、天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP））之间的独立关联。
对英国女性健康与心脏研究的基线数据进行横断面分析，该研究是对60 - 79岁英国女性的随机抽样。
腿长与年龄调整后的ALT、GGT和ALP水平呈负相关。在控制儿童期和成年期社会阶层、身体活动、吸烟、饮酒、腰臀比和躯干长度后，这些关联仍然存在。躯干长度与ALT呈正相关，与ALP呈负相关，在调整协变量后这些关联仍然存在。
成年期肝功能受早年环境暴露的影响，如腿长所反映的那样，这可能表明儿童期对肝脏发育以及成人患糖尿病和冠心病风险存在共同影响。对与腿长相关的早年暴露进行详细测量的进一步研究，对于确定导致成年期肝功能和心血管疾病的任何特定暴露因素将具有重要价值。
