粘蛋白1是Toll样受体信号传导的负调节因子。
MUC1 mucin is a negative regulator of toll-like receptor signaling.
作者信息
Ueno Keiko, Koga Takeshi, Kato Kosuke, Golenbock Douglas T, Gendler Sandra J, Kai Hirofumi, Kim K Chul
机构信息
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr., S.E., Albuquerque, NM 87108-5127, USA.
出版信息
Am J Respir Cell Mol Biol. 2008 Mar;38(3):263-8. doi: 10.1165/rcmb.2007-0336RC. Epub 2007 Dec 13.
Abstract
MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.
摘要
MUC1（人类中的MUC1和非人类物种中的Muc1）是一种跨膜粘蛋白样糖蛋白，在覆盖各种粘膜表面的上皮细胞以及造血细胞中表达。最近，我们发现与野生型同窝小鼠相比，Muc1基因敲除小鼠对铜绿假单胞菌或其鞭毛蛋白表现出更强的炎症反应，并且我们对培养细胞的研究表明，MUC1/Muc1抑制了Toll样受体（TLR）5信号通路，提示其具有抗炎作用。在此我们证明，其他TLR信号通路（TLR2、3、4、7和9）也受到MUC1/Muc1的抑制。本研究结果表明，MUC1/Muc1在各种病原菌和病毒引起的气道感染和炎症过程中可能起关键作用。
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