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1
MUC1 mucin is a negative regulator of toll-like receptor signaling.粘蛋白1是Toll样受体信号传导的负调节因子。
Am J Respir Cell Mol Biol. 2008 Mar;38(3):263-8. doi: 10.1165/rcmb.2007-0336RC. Epub 2007 Dec 13.
2
Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.膜结合型 MUC1 粘蛋白可被气道上皮细胞中的表皮生长因子受体磷酸化，并与 TLR5 结合以抑制 MyD88 的募集。
J Immunol. 2012 Feb 15;188(4):2014-22. doi: 10.4049/jimmunol.1102405. Epub 2012 Jan 16.
3
Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation.铜绿假单胞菌通过表皮生长因子受体（EGFR）激活刺激粘蛋白1（MUC1）胞质尾的酪氨酸磷酸化及Toll样受体5（TLR5）与之结合。
Inflamm Res. 2016 Mar;65(3):225-33. doi: 10.1007/s00011-015-0908-8. Epub 2015 Dec 8.
4
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice.前沿：Muc1基因敲除小鼠增强对铜绿假单胞菌的肺部清除能力
J Immunol. 2006 Apr 1;176(7):3890-4. doi: 10.4049/jimmunol.176.7.3890.
5
TNF-α is a key regulator of MUC1, an anti-inflammatory molecule, during airway Pseudomonas aeruginosa infection.TNF-α 是气道铜绿假单胞菌感染中 MUC1 的关键调节因子，MUC1 是一种抗炎分子。
Am J Respir Cell Mol Biol. 2011 Feb;44(2):255-60. doi: 10.1165/rcmb.2009-0323OC. Epub 2010 May 6.
6
Deletion of the mucin-like molecule muc1 enhances dendritic cell activation in response to toll-like receptor ligands.黏蛋白样分子 muc1 的缺失增强了树突状细胞对 Toll 样受体配体的激活。
J Innate Immun. 2010;2(2):123-43. doi: 10.1159/000254790. Epub 2009 Nov 2.
7
Anti-inflammatory effect of MUC1 during respiratory syncytial virus infection of lung epithelial cells in vitro.体外肺上皮细胞呼吸道合胞病毒感染时 MUC1 的抗炎作用。
Am J Physiol Lung Cell Mol Physiol. 2010 Apr;298(4):L558-63. doi: 10.1152/ajplung.00225.2009. Epub 2010 Jan 15.
8
MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli.黏蛋白 1（MUC1）和黏蛋白 13（MUC13）在应对炎症和感染性刺激时，可差异化调节上皮炎症。
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Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells.丹参酮 IIA 抑制脂多糖诱导的肺泡上皮细胞 MUC1 过度表达。
Am J Physiol Cell Physiol. 2014 Jan 1;306(1):C59-65. doi: 10.1152/ajpcell.00070.2013. Epub 2013 Oct 23.
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Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages.膜 tethered MUC1 粘蛋白对巨噬细胞的吞噬活性起反向调节作用。 （注：这里“tethered”不太明确准确意思，可能是“锚定的”之类意思，整体译文可能需根据更准确的原文信息微调）
Am J Respir Cell Mol Biol. 2016 Apr;54(4):515-23. doi: 10.1165/rcmb.2015-0177OC.

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MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome-mediated pyroptosis through the inhibition of the TLR4/MyD88/NF-κB pathway.黏蛋白 1 通过抑制 TLR4/MyD88/NF-κB 通路减少 NLRP3 炎性小体介导的焦亡，从而减轻哮喘中的中性粒细胞性气道炎症。
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Front Immunol. 2022 Apr 11;13:883079. doi: 10.3389/fimmu.2022.883079. eCollection 2022.
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本文引用的文献

1
Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling.磷酸肌醇3激酶由黏蛋白1激活，但不负责黏蛋白1诱导的Toll样受体5信号传导抑制。
Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L686-92. doi: 10.1152/ajplung.00423.2006. Epub 2007 Jun 22.
2
TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication.肿瘤坏死因子-α诱导肺上皮细胞中MUC1基因转录：其信号通路及生物学意义。
Am J Physiol Lung Cell Mol Physiol. 2007 Sep;293(3):L693-701. doi: 10.1152/ajplung.00491.2006. Epub 2007 Jun 15.
3
Cell surface-associated mucins in signal transduction.信号转导中的细胞表面相关黏蛋白。
Trends Cell Biol. 2006 Sep;16(9):467-76. doi: 10.1016/j.tcb.2006.07.006. Epub 2006 Aug 9.
4
TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression.Toll样受体5介导的磷酸肌醇3激酶激活对鞭毛蛋白诱导的促炎基因表达起负调控作用。
J Immunol. 2006 May 15;176(10):6194-201. doi: 10.4049/jimmunol.176.10.6194.
5
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice.前沿：Muc1基因敲除小鼠增强对铜绿假单胞菌的肺部清除能力
J Immunol. 2006 Apr 1;176(7):3890-4. doi: 10.4049/jimmunol.176.7.3890.
6
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3.Toll样受体介导的细胞因子产生受糖原合酶激酶3的差异调节。
Nat Immunol. 2005 Aug;6(8):777-84. doi: 10.1038/ni1221. Epub 2005 Jul 10.
7
Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages.脂多糖诱导的c-Src表达在巨噬细胞一氧化氮和肿瘤坏死因子α分泌中起作用。
Mol Immunol. 2006 Feb;43(4):308-16. doi: 10.1016/j.molimm.2005.03.015.
8
Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter.中性粒细胞弹性蛋白酶通过增加Sp1与MUC1启动子的结合来刺激MUC1基因表达。
Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L355-62. doi: 10.1152/ajplung.00040.2005. Epub 2005 Apr 22.
9
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex.c-Src在白细胞介素-1诱导的核因子κB激活中的功能作用：c-Src是IKK复合物的一个组成部分。
J Biochem. 2005 Feb;137(2):189-97. doi: 10.1093/jb/mvi018.
10
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.干扰素调节因子IRF5是Toll样受体7信号通路的核心介质。
J Biol Chem. 2005 Apr 29;280(17):17005-12. doi: 10.1074/jbc.M412584200. Epub 2005 Jan 28.

粘蛋白1是Toll样受体信号传导的负调节因子。

MUC1 mucin is a negative regulator of toll-like receptor signaling.

作者信息

Ueno Keiko, Koga Takeshi, Kato Kosuke, Golenbock Douglas T, Gendler Sandra J, Kai Hirofumi, Kim K Chul

机构信息

Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr., S.E., Albuquerque, NM 87108-5127, USA.

出版信息

Am J Respir Cell Mol Biol. 2008 Mar;38(3):263-8. doi: 10.1165/rcmb.2007-0336RC. Epub 2007 Dec 13.

DOI:10.1165/rcmb.2007-0336RC
PMID:18079492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2258447/
Abstract

MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.

摘要

MUC1（人类中的MUC1和非人类物种中的Muc1）是一种跨膜粘蛋白样糖蛋白，在覆盖各种粘膜表面的上皮细胞以及造血细胞中表达。最近，我们发现与野生型同窝小鼠相比，Muc1基因敲除小鼠对铜绿假单胞菌或其鞭毛蛋白表现出更强的炎症反应，并且我们对培养细胞的研究表明，MUC1/Muc1抑制了Toll样受体（TLR）5信号通路，提示其具有抗炎作用。在此我们证明，其他TLR信号通路（TLR2、3、4、7和9）也受到MUC1/Muc1的抑制。本研究结果表明，MUC1/Muc1在各种病原菌和病毒引起的气道感染和炎症过程中可能起关键作用。