Takahashi Yoshimitsu, Kiba Takayoshi, Yamaguchi Kayoko, Saitou Yoshimasa, Nishio Kouji, Iguch Masaharu, Motoo Yoshiharu
Dept. of Pharmacy, Kanazawa Medical University Hospital.
Gan To Kagaku Ryoho. 2007 Dec;34(13):2321-3.
We here describe a 49-year-old man who suffered repeated anaphylactic shock after systemic chemotherapy with vinorelbine for stage IV left lung adenocarcinoma (S1+2). He was treated using a combination of cisplatin and weekly irinotecan (CPT-11) as the first line; however, the regimen was changed to a combination of vinorelbine (VNR) and gemcitabine (GEM) because of his progressive disease. He was admitted to our hospital for examination of the unknown cause of hypotension and loss of consciousness. The second shock occurred after eating pistachios, and the third one at cancerous pain. After pain control, the shock no longer occurred. Anaphylactic shock may show two peaks and late symptoms. In patients with a history of anaphylactic shock, we should pay attention to foods, drugs, and various stresses which might cause anaphylaxis.
我们在此描述一名49岁男性，他在接受长春瑞滨全身化疗治疗IV期左肺腺癌（S1+2）后反复发生过敏性休克。他一线接受顺铂联合每周一次伊立替康（CPT-11）治疗；然而，由于疾病进展，治疗方案改为长春瑞滨（VNR）联合吉西他滨（GEM）。他因不明原因的低血压和意识丧失入院检查。第二次休克发生在食用开心果后，第三次发生在癌痛时。疼痛控制后，休克不再发生。过敏性休克可能呈现两个高峰和晚期症状。对于有过敏性休克病史的患者，我们应注意可能引发过敏反应的食物、药物和各种应激因素。
