Jiang Zhiqiang, Hao Jianyuan, You Yujing, Liu Yan, Wang Zhenhong, Deng Xianmo
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, People's Republic of China.
J Biomed Mater Res A. 2008 Oct;87(1):45-51. doi: 10.1002/jbm.a.31699.
The aqueous solutions of triblock copolymers of poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol) [PEG-P(CL-GA)-PEG] undergoing sol-gel transition as the temperature increases from 20 to 60 degrees C were successfully prepared. The thermogelling block copolymers were synthesized by subtle control of the hydrophilic/hydrophobic balance and the chain microstructures. The amphiphilic block copolymer formed micelles in aqueous solution, and the micelle aggregated as the temperature increased. The sol-gel transition of the copolymer aqueous solutions was studied focusing on the structure-property relationship. GA was incorporated into the polymer chain to prevent crystallization of PCL component and increase the polymer degradation. It is expected to be a promising long-term delivery system for pH-sensitive drugs, proteins, and genes.
成功制备了聚（乙二醇）-聚（ε-己内酯-乙交酯）-聚（乙二醇）[PEG-P(CL-GA)-PEG]三嵌段共聚物的水溶液，当温度从20℃升高到60℃时，该溶液会发生溶胶-凝胶转变。通过精细控制亲水/疏水平衡和链微观结构合成了热凝胶化嵌段共聚物。两亲性嵌段共聚物在水溶液中形成胶束，并且随着温度升高胶束发生聚集。重点研究了共聚物水溶液的溶胶-凝胶转变与结构-性能之间的关系。将乙交酯引入聚合物链中以防止聚己内酯组分结晶并增加聚合物降解。预计它将成为用于pH敏感药物、蛋白质和基因的有前景的长期递送系统。
