边缘型人格障碍中的地塞米松抑制试验：创伤后应激障碍症状的影响
Dexamethasone suppression test in borderline personality disorder: impact of PTSD symptoms.
作者信息
Wingenfeld Katja, Hill Andreas, Adam Bettina, Driessen Martin
机构信息
Department of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany.
出版信息
Psychiatry Clin Neurosci. 2007 Dec;61(6):681-3. doi: 10.1111/j.1440-1819.2007.01728.x.
The purpose of the present study was to investigate the impact of post-traumatic stress disorder (PTSD) symptoms on hypothalamic-pituitary-adrenal axis feedback regulation in 18 female patients with borderline personality disorder (BPD) and 21 healthy controls. Reduced feedback sensitivity was found in BPD patients with a low number of PTSD symptoms, while findings in the BPD group with a high number of PTSD symptoms did not differ from those in controls. The results suggest a hypo-suppression in the dexamethasone suppression test in BPD with few PTSD symptoms.
本研究的目的是调查创伤后应激障碍（PTSD）症状对18名边缘型人格障碍（BPD）女性患者和21名健康对照者下丘脑-垂体-肾上腺轴反馈调节的影响。在PTSD症状数量较少的BPD患者中发现反馈敏感性降低，而PTSD症状数量较多的BPD组的结果与对照组无异。结果表明，在PTSD症状较少的BPD患者中，地塞米松抑制试验存在低抑制现象。
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