Garner Belinda, Chanen Andrew M, Phillips Lisa, Velakoulis Dennis, Wood Stephen J, Jackson Henry J, Pantelis Christos, McGorry Patrick D
ORYGEN Research Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.
Psychiatry Res. 2007 Dec 15;156(3):257-61. doi: 10.1016/j.pscychresns.2007.05.001. Epub 2007 Oct 22.
This study used magnetic resonance imaging to examine pituitary gland volume (PGV) in teenage patients with a first presentation of borderline personality disorder (BPD). No difference in PGV was observed between healthy controls (n=20) and the total BPD cohort (n=20). However, within the BPD cohort, those exposed to childhood trauma (n=9) tended to have smaller pituitaries (-18%) than those with no history of childhood trauma (n=10). These preliminary findings suggest that exposure to childhood trauma, rather than BPD, per se, might be associated with reduced PGV, possibly reflecting hypothalamic-pituitary-adrenal axis dysfunction.
本研究采用磁共振成像技术，对首次出现边缘型人格障碍（BPD）的青少年患者的垂体体积（PGV）进行了检查。在健康对照组（n = 20）和整个BPD队列（n = 20）之间，未观察到PGV有差异。然而，在BPD队列中，那些经历过童年创伤的患者（n = 9）的垂体往往比没有童年创伤史的患者（n = 10）小（-18%）。这些初步研究结果表明，童年创伤暴露，而非BPD本身，可能与PGV减小有关，这可能反映了下丘脑-垂体-肾上腺轴功能障碍。
