精神障碍中 HPA 轴的改变：对记忆的影响及其与治疗干预的相关性。
HPA axis alterations in mental disorders: impact on memory and its relevance for therapeutic interventions.
机构信息
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf & Schön Klinik Hamburg-Eilbek, Germany.
出版信息
CNS Neurosci Ther. 2011 Dec;17(6):714-22. doi: 10.1111/j.1755-5949.2010.00207.x. Epub 2010 Dec 8.
Abstract
Dysfunctions in hypothalamic-pituitary-adrenal (HPA) axis have been reported for several mental disorders that are also often characterized by memory disturbances. It is now well established that glucocorticoids influence cognitive processes by enhancing memory consolidation and impairing memory retrieval. There is further evidence for an association between HPA axis related disturbances and memory function in mental disorders. The present selective review provides a brief overview of HPA axis dysfunction and its impact on memory function in major depressive disorder, posttraumatic stress disorder, and borderline personality disorder. Furthermore, the relevance of these findings for therapeutic intervention is discussed.
摘要
下丘脑-垂体-肾上腺（HPA）轴功能障碍已在多种精神障碍中报道，这些障碍通常也伴有记忆障碍。目前已经明确，糖皮质激素通过增强记忆巩固和损害记忆提取来影响认知过程。此外，HPA 轴相关障碍与精神障碍中的记忆功能之间存在关联的证据进一步得到证实。本选择性综述简要概述了 HPA 轴功能障碍及其对重性抑郁障碍、创伤后应激障碍和边缘型人格障碍的记忆功能的影响。此外，还讨论了这些发现对治疗干预的意义。
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