Michalak Pawel
Department of Biology, University of Texas Arlington, P.O. Box 19498, Arlington, TX 76019, USA.
Genomics. 2008 Mar;91(3):243-8. doi: 10.1016/j.ygeno.2007.11.002. Epub 2007 Dec 21.
Accumulating evidence indicates that gene order in eukaryotic genomes is not completely random and that genes with similar expression levels tend to be clustered within the same genomic neighborhoods. The mechanism behind these gene coexpression clusters is as yet unclear. In this article, plausible biochemical, genetic, evolutionary, and technological determinants of this pattern are briefly reviewed.
越来越多的证据表明，真核生物基因组中的基因顺序并非完全随机，且表达水平相似的基因倾向于聚集在同一基因组区域内。这些基因共表达簇背后的机制目前尚不清楚。在本文中，我们简要回顾了这种模式可能的生化、遗传、进化和技术决定因素。
