Nicholas Joyce S, Charles Jane M, Carpenter Laura A, King Lydia B, Jenner Walter, Spratt Eve G
Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, SC 29425, USA.
Ann Epidemiol. 2008 Feb;18(2):130-6. doi: 10.1016/j.annepidem.2007.10.013.
The purpose of this study was to determine the prevalence of autism spectrum disorders (ASD) and associated characteristics among 8-year-old children.
This is an ongoing active, population-based surveillance program conducted in South Carolina as part of the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. Cases from the state's first two study years (2000 and 2002) have been combined for analysis, resulting in surveillance of 47,726 children who are 8 years of age.
A total of 295 children met criteria for ASD, yielding a prevalence of 6.2 per 1000. The racial distribution of cases was similar to that of 8-year-old children in the study area, with boys more commonly affected than girls (3.1:1). Seventy-nine percent of cases were served in special education, 36% of these under Autism classification. Analyses by gender showed differences in diagnostic criteria and intellectual functioning. Girls more often were cognitively impaired (IQ <or= 70) than boys (72.7% vs. 56.4%), although among those most severely impaired (IQ <or= 34), boys and girls were equally represented.
Results indicate that ASDs affect 1 in 162 children 8 years of age in South Carolina. Continuing surveillance will permit assessment of potential changes in this prevalence estimate over time.
本研究旨在确定8岁儿童中自闭症谱系障碍(ASD)的患病率及相关特征。
这是一项正在进行的、基于人群的主动监测项目,在南卡罗来纳州开展,是疾病控制与预防中心自闭症及发育障碍监测网络的一部分。该州前两个研究年份(2000年和2002年)的病例已合并进行分析,共监测了47726名8岁儿童。
共有295名儿童符合ASD标准,患病率为每1000人中有6.2人。病例的种族分布与研究区域内8岁儿童的分布相似,男孩比女孩更常受影响(比例为3.1:1)。79%的病例接受特殊教育,其中36%属于自闭症分类。按性别分析显示,诊断标准和智力功能存在差异。女孩比男孩更常出现认知障碍(智商≤70)(72.7%对56.4%),不过在最严重受损(智商≤34)的儿童中,男孩和女孩的比例相同。
结果表明,在南卡罗来纳州,ASD影响每162名8岁儿童中的1名。持续监测将有助于评估这一患病率估计随时间的潜在变化。