Caballero A Enrique, Bousquet-Santos Kelb, Robles-Osorio Ludivina, Montagnani Valeria, Soodini Geetha, Porramatikul Sriurai, Hamdy Osama, Nobrega Antonio C L, Horton Edward S
Joslin Diabetes Center, Clinical Research Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Diabetes Care. 2008 Mar;31(3):576-82. doi: 10.2337/dc07-1540. Epub 2007 Dec 14.
We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism.
A total of 38 lean or obese Hispanic children and adolescents (10-18 years of age) were selected. The overweight group (n = 21) had a BMI >85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry.
The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 +/- 60.0 vs. 223.2 +/- 47.5 ng/ml, P = 0.047), tumor necrosis factor-alpha (2.57 +/- 1.1 vs. 1.74 +/- 0.6 pg/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P < 0.0001), plasminogen-activated inhibitor-1 (47.0 +/- 35.7 vs. 12.0 +/- 5.2 ng/ml, P < 0.0001), tissue plasminogen activator (6.1 +/- 1.9 vs. 4.1 +/- 0.8 ng/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 x 10(3), P = 0.031) and lower levels of adiponectin (8.7 +/- 3.3 vs. 12.6 +/- 5.2 microg/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6.
Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.
我们测量了糖耐量正常的肥胖西班牙裔/拉丁裔儿童和青少年的内皮功能障碍、血管炎症和促凝血的血浆标志物，并确定了它们与身体成分以及糖脂代谢指标之间的关系。
共选取了38名西班牙裔儿童和青少年（10 - 18岁），其中有瘦的也有肥胖的。超重组（n = 21）的BMI高于其年龄和性别的第85百分位数，瘦组（n = 17）的BMI在第25至50百分位数之间。研究包括口服葡萄糖耐量试验、血浆葡萄糖和脂质测量、几种内皮功能和炎症标志物，以及通过双能X线吸收法测定身体成分。
肥胖组的收缩压和血浆甘油三酯较高，且比瘦组更具胰岛素抵抗性。肥胖组的血浆可溶性细胞间黏附分子水平也更高（259.5±60.0对223.2±47.5 ng/ml，P = 0.047）、肿瘤坏死因子-α（2.57±1.1对1.74±0.6 pg/ml，P = 0.008）、高敏C反应蛋白（2.0对0.13 mg/l，P < 0.0001）、纤溶酶原激活物抑制剂-1（47.0±35.7对12.0±5.2 ng/ml，P < 0.0001）、组织纤溶酶原激活物（6.1±1.9对4.1±0.8 ng/ml，P = 0.001）以及白细胞计数（6.9对5.3×10³，P = 0.031），而脂联素水平较低（8.7±3.3对12.6±5.2 μg/ml，P = 0.022）。可溶性血管细胞黏附分子或白细胞介素-6未观察到显著差异。
糖耐量正常的超重西班牙裔儿童和青少年表现出与肥胖和胰岛素抵抗相关的内皮功能障碍和亚临床炎症的血浆标志物增加。这些异常可能使他们易患2型糖尿病和心血管疾病。
Zotero 插件