Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
Department of Urology, Raphaelsklinik, 48143 Münster, Germany.
Curr Issues Mol Biol. 2021 Oct 14;43(3):1606-1622. doi: 10.3390/cimb43030114.
In view of research suggesting a possible beneficial impact of vitamin D on systemic inflammatory response, the authors decided to investigate an influence of vitamin D supplementation on serum levels of certain inflammatory markers in obese patients. The current study included such biomarkers as interleukin-6 (IL-6), pituitary adenylate cyclase-activating peptide (PACAP), advanced oxidation protein products (AOPP), C-X3-C Motif Chemokine Ligand 1 (CX3CL1), monocyte chemoattractant protein-1 (MCP-1), and nitric oxide (NO). The measurements were performed with the ELISA method before and after 3-month-long supplementation of 2000 IU of vitamin D orally. The results showed that the therapy did not induce any statistically significant changes in serum levels of MCP-1, IL-6, CX3CL1, and PACAP. The supplementation was related to a significant increase in measurements of NO and AOPP levels, although the correlation analysis between vitamin D concentration after its supplementation and the concentration of the molecular parameters did not show significant relation. In conclusion, our study seems to contradict certain aspects of findings available in the literature regarding the vitamin D's impact.
鉴于研究表明维生素 D 可能对全身炎症反应产生有益影响，作者决定研究维生素 D 补充对肥胖患者血清中某些炎症标志物水平的影响。本研究包括白细胞介素 6（IL-6）、垂体腺苷酸环化酶激活肽（PACAP）、高级氧化蛋白产物（AOPP）、C-X3-C 基序趋化因子配体 1（CX3CL1）、单核细胞趋化蛋白-1（MCP-1）和一氧化氮（NO）等生物标志物。使用 ELISA 法在口服 2000IU 维生素 D 补充 3 个月前后进行了测量。结果表明，该治疗并未引起 MCP-1、IL-6、CX3CL1 和 PACAP 血清水平的任何统计学显著变化。补充与 NO 和 AOPP 水平的显著增加有关，尽管补充后维生素 D 浓度与分子参数浓度之间的相关分析并未显示出显著关系。总之，我们的研究似乎与文献中关于维生素 D 影响的某些方面相矛盾。
