磷酸盐对粘质沙雷氏菌次生代谢的抑制作用。
Phosphate inhibition of secondary metabolism in Serratia marcescens.
作者信息
Witney F R, Failla M L, Weinberg E D
出版信息
Appl Environ Microbiol. 1977 May;33(5):1042-6. doi: 10.1128/aem.33.5.1042-1046.1977.
Abstract
The synthesis of prodigiosin by non-proliferating cells of Serratia marcescens was examined in the presence of a wide range of concentrations of inorganic phosphate (Pi). A high elevation of pigment formation was obtained at less than or equal to 0.3 mM, and a broader but much lower elevation was obtained at 10 to 250 mM Pi. The synthesis of two immediate precursors of the pitment also was inhibited by Pi. The mechanism of action of Pi did not involve changes in pH or accumulation of the trace metal nutrient iron or zinc. Inhibition was most pronounced when Pi was added to the induction system before the onset of pigment formation. The inhibitor also diminished the burst of alkaline phosphatase activity that occurred in the period between the start of induction and appearance of prodigiosin.
摘要
在广泛浓度范围的无机磷酸盐（Pi）存在的情况下，研究了粘质沙雷氏菌非增殖细胞中灵菌红素的合成。在小于或等于0.3 mM时色素形成显著增加，在10至250 mM Pi时色素形成增加幅度更大但程度低得多。色素的两种直接前体的合成也受到Pi的抑制。Pi的作用机制不涉及pH值的变化或微量金属营养元素铁或锌的积累。当在色素形成开始之前将Pi添加到诱导系统中时，抑制作用最为明显。该抑制剂还减少了在诱导开始至灵菌红素出现期间发生的碱性磷酸酶活性的激增。
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