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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1026-8. doi: 10.1107/S1744309107051329. Epub 2007 Nov 21.
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本文引用的文献

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Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.核糖体S6激酶（RSK）在一个重要的调节位点上调节细丝蛋白A的磷酸化。
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Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity.p90核糖体S6激酶（RSK）的磷酸化调节细胞外信号调节激酶对接和RSK活性。
Mol Cell Biol. 2003 Jul;23(14):4796-804. doi: 10.1128/MCB.23.14.4796-4804.2003.
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Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK.核糖体S6激酶1（RSK1）的激活需要依赖和不依赖于丝裂原活化蛋白激酶ERK的信号。
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Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3.Rsk-2对表皮生长因子激活的组蛋白H3磷酸化的需求。
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A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1.卵母细胞成熟过程中 MAP 激酶与 p34(cdc2)/细胞周期蛋白 B 之间的联系：p90(rsk) 磷酸化并使 p34(cdc2) 抑制激酶 Myt1 失活。
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9
pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167.pp90rsk1通过Ser-167的磷酸化调节雌激素受体介导的转录。
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10
IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.核因子κB抑制蛋白α是丝裂原活化的90 kDa核糖体S6激酶的作用靶点。
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人源RSK1丝氨酸/苏氨酸蛋白激酶C端结构域的蛋白质制备、结晶及初步X射线分析

Protein preparation, crystallization and preliminary X-ray analysis of the C-terminal domain of human RSK1 serine/threonine protein kinase.

作者信息

Fu Tian-Min, Li Dan, Nan Jie, Li Lanfen, Xue Yafeng, Su Xiao-Dong

机构信息

College of Life Sciences, Peking University, Beijing 100871, People's Republic of China.

出版信息

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1026-8. doi: 10.1107/S1744309107051329. Epub 2007 Nov 21.

DOI:10.1107/S1744309107051329
PMID:18084084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2344107/
Abstract

As a substrate of extracellular signal-related kinase (ERK), the p90 ribosome S6 kinase 1 (RSK1) is at the terminus of the Ras/ERK pathway. Residues 411-735 of human RSK1, covering the C-terminal serine/threonine kinase catalytic domain and the functionally important tail, were cloned into an Escherichia coli expression vector. The protein was expressed, purified and crystallized. The crystals diffracted to 2.7 A and belonged to space group P2(1), with unit-cell parameters a = 39.8, b = 143.8, c = 59.9 A, beta = 95.7 degrees.

摘要

作为细胞外信号调节激酶（ERK）的底物，p90核糖体S6激酶1（RSK1）位于Ras/ERK信号通路的末端。将人RSK1的411 - 735位残基（覆盖C末端丝氨酸/苏氨酸激酶催化结构域和功能重要的尾部）克隆到大肠杆菌表达载体中。该蛋白经表达、纯化和结晶。晶体衍射分辨率达到2.7 Å，属于P2(1)空间群，晶胞参数为a = 39.8、b = 143.8、c = 59.9 Å，β = 95.7°。