TROP2 是喉鳞状细胞癌的潜在治疗靶点和独立预后标志物。
Potential therapeutic target and independent prognostic marker of TROP2 in laryngeal squamous cell carcinoma.
机构信息
Department of Otorhinolaryngology/Head and Neck Surgery, Nantong University Hospital, Nantong, Jiangsu, China.
出版信息
Head Neck. 2013 Oct;35(10):1373-8. doi: 10.1002/hed.23138. Epub 2012 Sep 18.
BACKGROUND
The human trophoblastic cell surface antigen 2 (TROP2) gene is associated with the development of malignancies, but its expression in laryngeal squamous cell carcinoma (SCC) and its relationship with clinical characteristics of the disease remain undetermined.
METHODS
Expression of TROP2 protein was detected by immunohistochemistry with a self-made anti-TROP2 antibody in laryngeal SCC tissue microarrays.
RESULTS
Elevated expression of TROP2 was detected in laryngeal SCC tissues compared with adjacent noncancerous tissues. TROP2 expression in laryngeal SCC was related to tumor differentiation (p = .0001) and lymph node metastasis (p = .0352). Cox regression analyses confirmed that TROP2 expression (p = .015), lymph node metastasis (p = .001), degree of differentiation (p = .002), tumor site (p = .021), and T classification (p = .003) were independent prognostic factors.
CONCLUSIONS
TROP2 can be used as an independent prognostic indicator for laryngeal SCC.
背景
人滋养层细胞表面抗原 2（TROP2）基因与恶性肿瘤的发生有关，但它在喉鳞状细胞癌（SCC）中的表达及其与疾病临床特征的关系尚不确定。
方法
采用自制的抗 TROP2 抗体通过免疫组织化学法检测喉 SCC 组织微阵列中 TROP2 蛋白的表达。
结果
与相邻非癌组织相比，TROP2 在喉 SCC 组织中表达升高。TROP2 在喉 SCC 中的表达与肿瘤分化（p=0.0001）和淋巴结转移（p=0.0352）有关。Cox 回归分析证实 TROP2 表达（p=0.015）、淋巴结转移（p=0.001）、分化程度（p=0.002）、肿瘤部位（p=0.021）和 T 分类（p=0.003）是独立的预后因素。
结论
TROP2 可作为喉 SCC 的独立预后指标。
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