Emmett M
Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX 75246, USA.
Kidney Int. 2008 Jan;73(1):3-5. doi: 10.1038/sj.ki.5002651.
Fibroblast growth factor 23 (FGF-23) is a phosphate-regulating substance largely produced by osteocytes. Its major action, in normal subjects, is the inhibition of Na-coupled reabsorption of inorganic phosphate in the renal proximal tubule. FGF-23 levels increase markedly in dialysis patients. Why do the FGF-23 levels increase in these patients, and do they have any physiologic or pathophysiologic effects?
成纤维细胞生长因子23（FGF - 23）是一种主要由骨细胞产生的磷酸盐调节物质。在正常受试者中，其主要作用是抑制肾近端小管中钠偶联的无机磷酸盐重吸收。透析患者的FGF - 23水平显著升高。为什么这些患者的FGF - 23水平会升高，以及它们是否具有任何生理或病理生理作用？
