来自植物细胞培养物的天然产物。

Natural products from plant cell cultures.

作者信息

McCoy Elizabeth, O'Connor Sarah E

机构信息

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

出版信息

Prog Drug Res. 2008;65:329, 331-70.

PMID:18084920

Abstract

Plants produce complex small molecules - natural products - that exhibit anticancer, antimalarial and antimicrobial activity. These molecules play a key role in human medicine. However, plants typically produce these compounds in low quantities, and harvesting plant natural products is frequently expensive, time-consuming and environmentally damaging. Plant cell culture provides a renewable, easily scalable source of plant material. In this chapter we discuss the successes and pitfalls associated with natural product production in plant cell cultures.

摘要

植物会产生复杂的小分子——天然产物，这些天然产物具有抗癌、抗疟疾和抗菌活性。这些分子在人类医学中发挥着关键作用。然而，植物通常产生这些化合物的量很少，而且收获植物天然产物往往成本高昂、耗时且对环境有害。植物细胞培养提供了一种可再生、易于扩大规模的植物材料来源。在本章中，我们将讨论与植物细胞培养中天然产物生产相关的成功经验和陷阱。