Stafford Angela M
Phytera Ltd, Regent Court, Regent Street, Sheffield, S1 4DA, UK.
Curr Opin Drug Discov Devel. 2002 Mar;5(2):296-303.
Plants have provided some of our most important pharmaceuticals and are a continuing source of novel bioactive molecules for drug development. Cell suspension cultures of higher plants are a complementary source of novel chemistry with significant advantages over whole plants, including plasticity of expression and re-accessibility. With an emphasis on recent progress, the use of plant cell cultures for both new lead discovery and as a route to the production of known bioactives will be described. Developments in strategies that can be applied to facilitate future success in the area are discussed.
植物提供了一些我们最重要的药物，并且是药物开发中新型生物活性分子的持续来源。高等植物的细胞悬浮培养是新型化学物质的补充来源，与整株植物相比具有显著优势，包括表达的可塑性和可再次获取性。本文将重点介绍近期进展，阐述利用植物细胞培养进行新先导化合物发现以及作为生产已知生物活性物质途径的情况。还将讨论可用于促进该领域未来成功的策略发展。
