Zelnak Amelia B
Emory University School of Medicine, Atlanta, GA, USA.
Methods Mol Med. 2007;137:209-34. doi: 10.1007/978-1-59745-442-1_15.
The microtubule-targeting agents have made significant contributions to cancer therapy over the past 50 years. The vinca alkaloids and taxanes have been used to treat a broad range of malignancies, including leukemias and lymphomas and many types of solid tumors. The taxanes have been frequently used in the treatment of advanced ovarian, breast, lung, head and neck, and prostate cancer, and they are increasingly being used in early stage disease. This chapter reviews the pharmacology, clinical indications, and toxicities associated with the vinca alkaloids and taxanes.
在过去50年里，微管靶向药物对癌症治疗做出了重大贡献。长春花生物碱和紫杉烷已被用于治疗多种恶性肿瘤，包括白血病、淋巴瘤以及多种实体瘤。紫杉烷常用于治疗晚期卵巢癌、乳腺癌、肺癌、头颈癌和前列腺癌，并且越来越多地用于早期疾病的治疗。本章综述了长春花生物碱和紫杉烷的药理学、临床适应证及毒性。
