Motoyama Osamu, Hasegawa Akira, Kawamura Takeshi, Aikawa Atushi, Iitaka Kikuo
Department of Pediatrics, Toho University Medical Center, Sakura Hospital, 564-1 Shimoshizu, Sakura-shi, Chiba, 285-8741, Japan.
Department of Nephrology, Toho University Medical Center, Omori Hospital, Tokyo, Japan.
Clin Exp Nephrol. 2007 Dec;11(4):332-335. doi: 10.1007/s10157-007-0491-6. Epub 2007 Dec 21.
Three girls with normal growth hormone secretion had received renal transplantation when aged 2 to 6 years. They had had severely retarded growth (SD for height score was -7.4 to -3.7) at the time of transplantation. After renal transplantation, steroid was withdrawn and they were treated with recombinant human growth hormone; they subsequently reached adult heights of 145 to 156 cm. The SD for adult height score was -2.6 to -0.3. The adult height in two patients was over their target height, calculated using the mean of the parents' height. This report shows the efficacy of steroid withdrawal and recombinant human growth hormone therapy in achieving adult height in these three girls after renal transplantation.
三名生长激素分泌正常的女孩在2至6岁时接受了肾移植。移植时她们的生长严重迟缓（身高评分标准差为-7.4至-3.7）。肾移植后，停用了类固醇，并用重组人生长激素进行治疗；她们随后达到了145至156厘米的成人身高。成人身高评分标准差为-2.6至-0.3。两名患者的成人身高超过了根据父母身高平均值计算出的目标身高。本报告显示了停用类固醇和重组人生长激素疗法对这三名肾移植后女孩实现成人身高的疗效。
