Tykarski A
Kliniki Nadciśnienia Tetniczego Instytutu Kardiologii AM w Poznaniu.
Pol Arch Med Wewn. 1991 Sep;86(3):159-66.
In forty patients with mild to moderate essential hypertension and in twenty healthy subjects serum uric acid was measured and parameters of renal excretion of urate were evaluated. Serum uric acid concentration and prevalence of hyperuricemia were significantly higher in hypertensive patients. Patients with essential hypertension and concomitant hyperuricemia showed significantly decreased clearance and fractional excretion of uric acid in comparison with normotensive subjects. Adverse correlation between serum uric acid and clearance as well as fractional excretion of urate found in hypertensive patients indicates that high prevalence of hyperuricemia in essential hypertension is caused by impaired renal excretion of uric acid.
对40例轻至中度原发性高血压患者和20名健康受试者测定了血清尿酸，并评估了尿酸肾排泄参数。高血压患者的血清尿酸浓度和高尿酸血症患病率显著更高。与血压正常的受试者相比，原发性高血压合并高尿酸血症的患者尿酸清除率和尿酸排泄分数显著降低。高血压患者血清尿酸与尿酸清除率以及尿酸排泄分数之间的负相关表明，原发性高血压中高尿酸血症的高患病率是由尿酸肾排泄受损所致。
