Rajasekaran Sigrid A, Beyenbach Klaus W, Rajasekaran Ayyappan K
The Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA.
Biochim Biophys Acta. 2008 Mar;1778(3):757-69. doi: 10.1016/j.bbamem.2007.11.007. Epub 2007 Nov 19.
Tight junctions are unique organelles in epithelial cells. They are localized to the apico-lateral region and essential for the epithelial cell transport functions. The paracellular transport process that occurs via tight junctions is extensively studied and is intricately regulated by various extracellular and intracellular signals. Fine regulation of this transport pathway is crucial for normal epithelial cell functions. Among factors that control tight junction permeability are ions and their transporters. However, this area of research is still in its infancy and much more needs to be learned about how these molecules regulate tight junction structure and functions. In this review we have attempted to compile literature on ion transporters and channels involved in the regulation of tight junctions.
紧密连接是上皮细胞中的独特细胞器。它们定位于顶侧区域，对上皮细胞的转运功能至关重要。通过紧密连接发生的细胞旁转运过程已得到广泛研究，并受到各种细胞外和细胞内信号的复杂调控。对该转运途径的精细调节对于正常上皮细胞功能至关重要。控制紧密连接通透性的因素包括离子及其转运体。然而，这一研究领域仍处于起步阶段，关于这些分子如何调节紧密连接的结构和功能还有很多需要了解的地方。在这篇综述中，我们试图汇编有关参与紧密连接调节的离子转运体和通道的文献。
