Cho Eunyoung, Holmes Michelle, Hankinson Susan E, Willett Walter C
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2787-90. doi: 10.1158/1055-9965.EPI-07-0683.
Folate, vitamin B6, vitamin B12, methionine, choline, and betaine are nutrients involved in one-carbon metabolism and have been hypothesized to reduce the risk of breast cancer. However, previous epidemiologic studies on most of these nutrients and breast cancer risk have been inconclusive and have included primarily postmenopausal women. No study has examined choline and betaine in relation to breast cancer risk. Therefore, we examined the intake of these nutrients in relation to breast cancer risk among 90,663 premenopausal women ages 26 to 46 years in 1991 in the Nurses' Health Study II. Nutrient intake was assessed with a validated food frequency questionnaire in 1991, 1995, and 1999. During 12 years of follow-up from 1991 to 2003, we documented 1,032 incident cases of invasive breast cancer. Overall, none of the nutrients was associated with risk of breast cancer. The results were similar by levels of alcohol intake and folate intake and for estrogen receptor-negative breast cancer. In conclusion, we found no evidence that higher intakes of nutrients involved in one-carbon metabolism reduce risk of breast cancer among premenopausal women.
叶酸、维生素B6、维生素B12、蛋氨酸、胆碱和甜菜碱是参与一碳代谢的营养素，据推测它们可降低患乳腺癌的风险。然而，此前关于这些营养素中大多数与乳腺癌风险的流行病学研究尚无定论，且主要纳入的是绝经后女性。尚无研究探讨胆碱和甜菜碱与乳腺癌风险的关系。因此，在护士健康研究II中，我们调查了1991年年龄在26至46岁的90663名绝经前女性中这些营养素的摄入量与乳腺癌风险的关系。1991年、1995年和1999年通过一份经过验证的食物频率问卷评估营养素摄入量。在1991年至2003年的12年随访期间，我们记录了1032例浸润性乳腺癌新发病例。总体而言，没有一种营养素与乳腺癌风险相关。按酒精摄入量和叶酸摄入量水平以及雌激素受体阴性乳腺癌分析，结果相似。总之，我们没有发现证据表明，增加参与一碳代谢的营养素摄入量可降低绝经前女性患乳腺癌的风险。
