Li Jian Ping, Huo Yong, Liu Ping
Department of Cardiology, Peking University First Hospital, Beijing 100034, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2007 Dec 18;39(6):614-8.
To investigate the efficacy and safety of Enalapril-Folic acid tablets in lowering blood pressure and plasma homocysteine(Hcy) level.
A randomized, double blind, multicenter clinical trial was performed. Subjects with mild-moderate hypertension were randomly assigned to the following three groups: group 1, Enalapril 10.0 mg/d; group 2, Enalapril 10.0 mg+ Folic acid 0.4 mg/d; group 3, Enalapril 10.0 mg + Folic acid 0.8 mg/d. Blood pressure and plasma Hcy level were examined every two weeks, for a total period of 8 weeks.
A total of 480 hypertensives were enrolled. All analyses were performed according to the intention to treat and included all randomized patients. Compared to group 1, both group 2 and group 3 had significantly higher effectiveness in lowering both blood pressure and plasma Hcy level, or in lowering either blood pressure or plasma Hcy level. The proportions of subjects showing obvious reduction in both blood pressure and plasma homocysteine level in group 1, group 2, group 3, were 4.6%, 13.2%, 17.1%, respectively; the proportions of subjects showing obvious reduction in either blood pressure or plasma homocysteine level in group 1, group 2, group 3, were 45.8%, 59.6%, and 65.1%, respectively; Effects on blood pressure, as well as the safety profile were not significantly different among the three regimens.
Enalapril-Folic acid tablets could be used to reduce both blood pressure and plasma Hcy level in mild to moderate hypertensive subjects.
探讨依那普利叶酸片降低血压及血浆同型半胱氨酸（Hcy）水平的疗效和安全性。
进行一项随机、双盲、多中心临床试验。轻中度高血压患者被随机分为以下三组：第1组，依那普利10.0mg/d；第2组，依那普利10.0mg+叶酸0.4mg/d；第3组，依那普利10.0mg+叶酸0.8mg/d。每两周检测血压和血浆Hcy水平，共8周。
共纳入480例高血压患者。所有分析均按照意向性治疗原则进行，纳入所有随机分组的患者。与第1组相比，第2组和第3组在降低血压和血浆Hcy水平方面，或在降低血压或血浆Hcy水平方面均有显著更高的疗效。第1组、第2组、第3组中血压和血浆同型半胱氨酸水平均明显降低的受试者比例分别为4.6%、13.2%、17.1%；第1组、第2组、第3组中血压或血浆同型半胱氨酸水平明显降低的受试者比例分别为45.8%、59.6%、65.1%；三种治疗方案对血压的影响以及安全性方面无显著差异。
依那普利叶酸片可用于降低轻中度高血压患者的血压和血浆Hcy水平。
