Stangerup S-E, Caye-Thomasen P, Tos M, Thomsen J
ENT Department, Gentofte University Hospital, Copenhagen, Denmark.
J Laryngol Otol. 2008 Jul;122(7):673-81. doi: 10.1017/S0022215107001077. Epub 2007 Dec 19.
To evaluate hearing changes during 'wait and scan' management of patients with vestibular schwannoma.
Over a 10-year period, 636 patients have prospectively been allocated to 'wait and scan' management, with annual magnetic resonance scanning and audiological examination.
At the time of diagnosis, 334 patients (53 per cent) had good hearing and speech discrimination of better than 70 per cent; at the end of the 10-year observation period, this latter percentage was 31 per cent. In 17 per cent of the patients, speech discrimination at diagnosis was 100 per cent; of these, 88 per cent still had good hearing at the end of the observation period. However, in patients with even a small initial speech discrimination loss, only 55 per cent maintained good hearing at the end of the observation period.
After comparing the hearing results of hearing preservation surgery and of radiation therapy with those of 'wait and scan' management, it appears that, in vestibular schwannoma patients with a small tumour and normal speech discrimination, the main indication for active treatment should be established tumour growth.
评估前庭神经鞘瘤患者“观察与扫描”管理期间的听力变化。
在10年期间,636例患者被前瞻性地分配至“观察与扫描”管理,进行年度磁共振扫描和听力检查。
诊断时,334例患者(53%)听力良好且言语辨别率优于70%;在10年观察期结束时,后一比例为31%。17%的患者诊断时言语辨别率为100%;其中,88%在观察期结束时仍听力良好。然而,即使初始言语辨别率仅有轻微损失的患者,在观察期结束时只有55%保持良好听力。
将听力保留手术和放射治疗的听力结果与“观察与扫描”管理的结果进行比较后发现,对于肿瘤较小且言语辨别正常的前庭神经鞘瘤患者,积极治疗的主要指征应为已确定的肿瘤生长。