Cianchetta-Sívori Malena, Raso Sandra, Fernández-Guerrero Manuel, Górgolas Miguel, García Rosa
Department of Immunology, Fundación Jimenez Díaz-Capio, Madrid, Spain.
AIDS. 2007 Nov 12;21(17):2347-9. doi: 10.1097/QAD.0b013e3282f125da.
Although undesirable, immune reconstitution syndrome (IRS) indicates a favourable effect of HAART and it should be differentiated from an opportunistic infection because of their distinct implications and management. Our group analysed different immunological parameters with the aim of identifying IRS predictors in patients who begin HAART. We found that CD8(+)CD25(+) cell pretreatment values in patients who developed IRS were four times higher than in those patients who did not develop IRS.
尽管免疫重建综合征（IRS）并不理想，但它表明了高效抗逆转录病毒治疗（HAART）的良好效果，并且由于其不同的影响和处理方式，应将其与机会性感染区分开来。我们团队分析了不同的免疫学参数，目的是确定开始接受HAART治疗的患者中IRS的预测指标。我们发现，发生IRS的患者的CD8(+)CD25(+)细胞预处理值是未发生IRS的患者的四倍。
