Kolber Michael A
Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
AIDS. 2008 Oct 1;22(15):1937-41. doi: 10.1097/QAD.0b013e32830f97e2.
Studies have found that CD8 T-cell activation, as measured by CD38 expression, in HIV-1-infected individuals on suppressive therapy for longer than 12 months is not predictive of CD4 T-cell recovery. Owing to the fact that reconstitution of memory and naive T-cell populations occurs differentially over time, this study evaluated whether distinct memory/naive CD4 T-cell subsets correlated with CD38 on CD8 T-cells.
Whole blood from 13 participants was used to evaluate activation phenotypic markers on CD8 lymphocytes and memory/naive phenotypes on CD4 lymphocytes. These HIV-1-infected individuals had stable CD4 cell counts for more than 1 year while on suppressive combination antiretroviral therapy.
The results demonstrate that CD4 central memory and naive cell populations contribute to the magnitude of CD4 T-cell reconstitution. CD4 central memory has a significant negative correlation with the percentage of CD38-activated CD8 T-cells.
This suggests that CD8 activation is important in CD4 recovery from a low CD4 T-cell nadir.
研究发现，对于接受抑制性治疗超过12个月的HIV-1感染者，通过CD38表达来衡量的CD8 T细胞活化并不能预测CD4 T细胞的恢复情况。鉴于记忆性和初始T细胞群体的重建随时间的变化存在差异，本研究评估了不同的记忆/初始CD4 T细胞亚群是否与CD8 T细胞上的CD38相关。
使用13名参与者的全血来评估CD8淋巴细胞上的活化表型标志物以及CD4淋巴细胞上的记忆/初始表型。这些HIV-1感染者在接受联合抗逆转录病毒抑制治疗期间，CD4细胞计数稳定超过1年。
结果表明，CD4中枢记忆细胞和初始细胞群体对CD4 T细胞重建的程度有贡献。CD4中枢记忆细胞与CD38活化的CD8 T细胞百分比呈显著负相关。
这表明CD8活化在CD4 T细胞从低水平最低点恢复过程中很重要。
