Hung Tai-Hsin, Lee Yu, Chang Yung-Yee, Chong Mian-Yoon, Lin Pao-Yen
Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Clin Neuropharmacol. 2007 Nov-Dec;30(6):370-2. doi: 10.1097/WNF.0b013e31805930e3.
Pisa syndrome, manifested with persistent lateral flexion of the trunk, is most commonly associated with prolonged treatment with typical antipsychotics. However, it was also reported as occurring with atypical antipsychotics. To our knowledge, there have been very few reports of clozapine-associated Pisa syndrome. Here we report 1 case of Pisa syndrome in a 39-year-old woman with schizoaffective disorder who developed tonic flexion of trunk and head toward the left side after clozapine treatment (400 mg/d) for 5 months. Clozapine was reduced to 25 mg/d within 15 days; the dystonic reaction then completely resolved within the next 3 to 4 weeks. Caution should be taken while prolonged use of clozapine in patients with risk factors of Pisa syndrome.
比萨综合征表现为躯干持续向一侧屈曲，最常与使用典型抗精神病药物进行长期治疗有关。然而，也有报道称非典型抗精神病药物也会引发该症状。据我们所知，关于氯氮平相关的比萨综合征的报道非常少。在此，我们报告1例39岁患有分裂情感性障碍的女性患者，在接受氯氮平治疗（400毫克/天）5个月后出现躯干和头部向左侧强直性屈曲。在15天内将氯氮平剂量减至25毫克/天；然后在接下来的3至4周内，肌张力障碍反应完全消失。对于有比萨综合征风险因素的患者，长期使用氯氮平时应谨慎。
