Wilken Jeffrey A, Sullivan Cynthia
Georgetown University Medical Center, Department of Neurology, Washington, District of Columbia, USA.
Neurologist. 2007 Nov;13(6):343-54. doi: 10.1097/NRL.0b013e31806dc2e8.
The rate of depression and other psychiatric disorders is greater in multiple sclerosis (MS) than in other chronic conditions or neurologic diseases. This means that clinical neurologists seeing MS patients will frequently be engaged in the diagnosis and treatment of psychiatric distress.
This review provides a summary of what is known about psychiatric dysfunction in MS. It offers information about the current views on the link between various psychiatric disorders and MS. More important, it offers suggestions on how the knowledge from existing research can be integrated into real-world practice.
Clinicians need to understand the factors that influence the development of psychiatric disorders in MS, the relationship between disease-modifying therapies and psychiatric distress, and the issues surrounding the treatment of psychiatric conditions in MS. Thorough knowledge of psychiatric dysfunction and MS will allow the clinician to design an effective treatment regimen that helps patients cope with their disease.
多发性硬化症（MS）患者中抑郁症及其他精神障碍的发病率高于其他慢性疾病或神经疾病。这意味着诊治MS患者的临床神经科医生常常需要参与精神困扰的诊断和治疗。
本综述总结了关于MS患者精神功能障碍的已知情况。它提供了有关各种精神障碍与MS之间联系的当前观点的信息。更重要的是，它就如何将现有研究中的知识整合到实际临床实践中提出了建议。
临床医生需要了解影响MS患者精神障碍发生发展的因素、疾病修正治疗与精神困扰之间的关系，以及MS患者精神疾病治疗中存在的问题。全面了解精神功能障碍与MS将使临床医生能够设计出有效的治疗方案，帮助患者应对疾病。
