Neukamm Merja A, Pinto Antonio, Metzler-Nolte Nils
Lehrstuhl für Anorganische Chemie I - Bioanorganische Chemie, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätstr. 150, D - 44801 Bochum, Germany.
Chem Commun (Camb). 2008 Jan 14(2):232-4. doi: 10.1039/b712886j. Epub 2007 Oct 22.
A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co(2)(CO)(8) to give the Co(2)(CO)(6)-alkyne labeled peptide , which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.
神经肽亮氨酸脑啡肽（Enk）的固相合成炔丙基衍生物与Co₂(CO)₈快速定量反应，生成Co₂(CO)₆-炔烃标记的肽，这是首个对两种不同肿瘤细胞系显示出显著毒性的有机金属肽生物共轭物。
