探讨金属配合物的细胞积累。
Exploring the cellular accumulation of metal complexes.
机构信息
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
出版信息
Dalton Trans. 2010 Feb 7;39(5):1159-70. doi: 10.1039/b922209j. Epub 2009 Dec 23.
Abstract
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.
摘要
过渡金属配合物作为诊断和治疗试剂具有巨大的潜力，越来越多的生物应用已经得到了探索。为了有效，这些配合物必须到达细胞内的预期靶点。在这里，我们回顾了金属配合物的细胞积累，包括它们的摄取、定位和外排。金属配合物通过多种机制被细胞摄取，包括被动扩散和通过有机和金属转运体进入。重点介绍了用于检查细胞积累、确定摄取机制以及监测可能的外排的方法。还描述了为了提高金属配合物的细胞摄取特性而采用的偶联策略。
相似文献
1
Exploring the cellular accumulation of metal complexes.探讨金属配合物的细胞积累。
Dalton Trans. 2010 Feb 7;39(5):1159-70. doi: 10.1039/b922209j. Epub 2009 Dec 23.
2
Application of d6 transition metal complexes in fluorescence cell imaging.d6 过渡金属配合物在荧光细胞成像中的应用。
Chem Commun (Camb). 2010 Jan 14;46(2):186-202. doi: 10.1039/b917757d. Epub 2009 Nov 12.
3
Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.闪耀生物系统之光：用于生物成像和生物传感应用的发光过渡金属配合物。
Chem Rev. 2024 Aug 14;124(15):8825-9014. doi: 10.1021/acs.chemrev.3c00629. Epub 2024 Jul 25.
4
Complexes in context: attempting to control the cellular uptake and localisation of rhenium fac-tricarbonyl polypyridyl complexes.语境中的配合物：尝试控制铼 fac-三羰基多吡啶配合物的细胞摄取和定位。
Dalton Trans. 2011 Nov 28;40(44):11663-74. doi: 10.1039/c1dt11219h. Epub 2011 Sep 6.
5
Molecular Design of Bioorthogonal Probes and Imaging Reagents Derived from Photofunctional Transition Metal Complexes.基于光功能化过渡金属配合物的生物正交探针和成像试剂的分子设计。
Acc Chem Res. 2020 Jan 21;53(1):32-44. doi: 10.1021/acs.accounts.9b00416. Epub 2020 Jan 9.
6
Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7.抗癌过渡金属茂和金属配合物：第 4 族到第 7 族元素
Molecules. 2024 Feb 11;29(4):824. doi: 10.3390/molecules29040824.
7
New trends in the optical and electronic applications of polymers containing transition-metal complexes.含过渡金属配合物的聚合物在光电子学中的新应用趋势。
Macromol Rapid Commun. 2012 Apr 13;33(6-7):461-80. doi: 10.1002/marc.201100775. Epub 2012 Mar 5.
8
Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery.具有生物活性配体的过渡金属配合物：选择性配体释放机制及药物递送应用
Metallomics. 2014 Aug;6(8):1324-35. doi: 10.1039/c4mt00069b.
9
Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.过渡金属配合物可见光光氧化还原催化：在有机合成中的应用
Chem Rev. 2013 Jul 10;113(7):5322-63. doi: 10.1021/cr300503r. Epub 2013 Mar 19.
10
Luminescent and Photofunctional Transition Metal Complexes: From Molecular Design to Diagnostic and Therapeutic Applications.发光和光功能化过渡金属配合物：从分子设计到诊断和治疗应用。
J Am Chem Soc. 2022 Aug 17;144(32):14420-14440. doi: 10.1021/jacs.2c03437. Epub 2022 Aug 4.
引用本文的文献
1
Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half-Sandwich Ir(III) Tetrazine Complex in Live Cells.生物正交后标记揭示了一种高细胞毒性的半夹心铱（III）四嗪配合物在活细胞中的核定位。
Chembiochem. 2025 Jun 16;26(12):e202500090. doi: 10.1002/cbic.202500090. Epub 2025 Apr 14.
2
Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation.金属离子对细胞功能的影响：以间充质干细胞/基质细胞分化为例。
Int J Mol Sci. 2024 Sep 20;25(18):10127. doi: 10.3390/ijms251810127.
3
MeXpose-A Modular Imaging Pipeline for the Quantitative Assessment of Cellular Metal Bioaccumulation.MeXpose——一种用于细胞金属生物累积定量评估的模块化成像流程
JACS Au. 2024 May 28;4(6):2197-2210. doi: 10.1021/jacsau.4c00154. eCollection 2024 Jun 24.
4
Combining cisplatin and a STING agonist into one molecule for metalloimmunotherapy of cancer.将顺铂和一种STING激动剂结合成一个分子用于癌症的金属免疫疗法。
Natl Sci Rev. 2024 Jan 17;11(1):nwae020. doi: 10.1093/nsr/nwae020. eCollection 2024 Jan.
5
Ir(III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy.具有π-扩展配体的 Ir(III) 半三明治光增敏剂用于高效的抗癌光动力治疗。
J Med Chem. 2024 Feb 8;67(3):1783-1811. doi: 10.1021/acs.jmedchem.3c01276. Epub 2024 Jan 30.
6
Polycationic Ru(II) Luminophores: Syntheses, Photophysics, and Application in Electrostatically Driven Sensitization of Lanthanide Luminescence.聚阳离子钌（II）发光体：合成、光物理性质及其在静电驱动的镧系元素发光敏化中的应用
Inorg Chem. 2023 Dec 4;62(48):19446-19456. doi: 10.1021/acs.inorgchem.3c02352. Epub 2023 Nov 20.
7
A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin.一种生成单加合物的钌（II）配合物可诱导核糖体生物合成应激，并且是菲曲铂的分子模拟物。
RSC Chem Biol. 2023 Feb 27;4(5):344-353. doi: 10.1039/d2cb00247g. eCollection 2023 May 10.
8
Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff Base.含席夫碱新型金属配合物的绿色合成、表征、抗菌及抗癌筛选
ACS Omega. 2022 Aug 26;7(36):32418-32431. doi: 10.1021/acsomega.2c03911. eCollection 2022 Sep 13.
9
Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy.低剂量近红外光激活的线粒体靶向光动力治疗癌症光敏剂。
Int J Mol Sci. 2022 Aug 23;23(17):9525. doi: 10.3390/ijms23179525.
10
Tuning the Biological Activity of Camphorimine Complexes through Metal Selection.通过金属选择调节樟脑亚胺配合物的生物活性
Antibiotics (Basel). 2022 Jul 27;11(8):1010. doi: 10.3390/antibiotics11081010.
本文引用的文献
1
Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells.用于贴壁肿瘤细胞中金属化合物摄取研究的实验方案的制定。
J Anal At Spectrom. 2009 Jan;24(1):51-61. doi: 10.1039/B810481F.
2
ABC efflux pump-based resistance to chemotherapy drugs.基于ABC外排泵的化疗药物耐药性。
Chem Rev. 2009 Jul;109(7):2989-3011. doi: 10.1021/cr9000226.
3
Fluorescein redirects a ruthenium-octaarginine conjugate to the nucleus.荧光素将钌 - 八聚精氨酸共轭物重定向至细胞核。
J Am Chem Soc. 2009 Jul 1;131(25):8738-9. doi: 10.1021/ja9025165.
4
Synthesis, properties, and live-cell imaging studies of luminescent cyclometalated iridium(III) polypyridine complexes containing two or three biotin pendants.含有两个或三个生物素侧链的发光环金属化铱(III)多吡啶配合物的合成、性质及活细胞成像研究。
Inorg Chem. 2009 Jul 6;48(13):6011-25. doi: 10.1021/ic900412n.
5
Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.在已注册药物中鉴定人类三大ATP结合盒转运蛋白P-糖蛋白、乳腺癌耐药蛋白和多药耐药相关蛋白2的新型特异性和通用抑制剂。
Pharm Res. 2009 Aug;26(8):1816-31. doi: 10.1007/s11095-009-9896-0. Epub 2009 May 7.
6
Synthesis and characterization of dicobalthexacarbonyl-alkyne derivatives of amino acids, peptides, and peptide nucleic acid (PNA) monomers.氨基酸、肽和肽核酸（PNA）单体的二羰基六羰基钴-炔烃衍生物的合成与表征。
Inorg Chem. 2009 Apr 6;48(7):3157-66. doi: 10.1021/ic900013r.
7
Mechanisms of endocytosis.内吞作用的机制。
Annu Rev Biochem. 2009;78:857-902. doi: 10.1146/annurev.biochem.78.081307.110540.
8
The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation.
Org Biomol Chem. 2009 Mar 7;7(5):851-5. doi: 10.1039/b822145f. Epub 2009 Jan 14.
9
Cell-penetrating metal complex optical probes: targeted and responsive systems based on lanthanide luminescence.细胞穿透性金属配合物光学探针：基于镧系发光的靶向和响应系统
Acc Chem Res. 2009 Jul 21;42(7):925-37. doi: 10.1021/ar800174z.
10
DNA mismatch binding and antiproliferative activity of rhodium metalloinsertors.铑金属插入剂的DNA错配结合及抗增殖活性
J Am Chem Soc. 2009 Feb 18;131(6):2359-66. doi: 10.1021/ja8081044.
Zotero 插件