Booth Brian W, Smith Gilbert H
Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Growth Factors. 2007 Aug;25(4):227-35. doi: 10.1080/08977190701750698.
Transforming growth factor-alpha (TGFalpha) is a member of the epidermal growth factor (EGF) family. Expression of TGFalpha is highly regulated in response to exogenous cellular signals including cytokines and other growth factors. The growth factor has been found to be indispensable for proper development of many tissues and organs. TGFalpha has also been implicated in numerous disease states including forms of breast cancer. This minireview summarizes the basic biology of TGFalpha and its actions during normal and pathogenic development of the mammary epithelium.
转化生长因子-α（TGFα）是表皮生长因子（EGF）家族的一员。TGFα的表达受包括细胞因子和其他生长因子在内的外源性细胞信号的高度调控。已发现该生长因子对许多组织和器官的正常发育不可或缺。TGFα还与包括多种乳腺癌在内的众多疾病状态有关。本综述总结了TGFα的基本生物学特性及其在乳腺上皮正常和致病发育过程中的作用。
