Department of Animal Science, University of California, Davis, One Shields Avenue, Davis, CA, 95616, USA.
Department of Veterinary Science, University of Turin, Largo Paolo Braccini 2, Grugliasco, TO, 10095, Italy.
J Mammary Gland Biol Neoplasia. 2023 May 23;28(1):10. doi: 10.1007/s10911-023-09538-w.
The ERBB tyrosine kinase receptors and their ligands belong to a complex family that has diverse biological effects and expression profiles in the developing mammary glands, where its members play an essential role in translating hormone signals into local effects. While our understanding of these processes stems mostly from mouse models, there is the potential for differences in how this family functions in the mammary glands of other species, particularly in light of their unique histomorphological features. Herein we review the postnatal distribution and function of ERBB receptors and their ligands in the mammary glands of rodents and humans, as well as for livestock and companion animals. Our analysis highlights the diverse biology for this family and its members across species, the regulation of their expression, and how their roles and functions might be modulated by varying stromal composition and hormone interactions. Given that ERBB receptors and their ligands have the potential to influence processes ranging from normal mammary development to diseased states such as cancer and/or mastitis, both in human and veterinary medicine, a more complete understanding of their biological functions should help to direct future research and the identification of new therapeutic targets.
ERBB 酪氨酸激酶受体及其配体属于一个复杂的家族，在发育中的乳腺中有多种生物学效应和表达谱，其成员在将激素信号转化为局部效应方面发挥着重要作用。虽然我们对这些过程的理解主要来自于小鼠模型，但该家族在其他物种的乳腺中的功能可能存在差异，特别是考虑到它们独特的组织形态学特征。本文综述了 ERBB 受体及其配体在啮齿动物和人类、家畜和伴侣动物乳腺中的产后分布和功能。我们的分析强调了该家族及其成员在不同物种中的多样性生物学、它们的表达调控以及它们的作用和功能如何通过不同的基质组成和激素相互作用进行调节。鉴于 ERBB 受体及其配体有可能影响从正常乳腺发育到癌症和/或乳腺炎等疾病状态的各种过程，无论是在人类医学还是兽医医学中，对其生物学功能的更全面了解应该有助于指导未来的研究和确定新的治疗靶点。
