Gupta Suprita, Rajagopal Ganapathy
Department of Biochemistry, National Medical College, Birgunj, Nepal.
Nepal Med Coll J. 2007 Sep;9(3):212-4.
High Density Lipoprotein (HDL) transports in plasma, phospholipids, cholesterol, and triacylglycerol. The cholesterol associated with HDL (HDLc) is cholesterol that is scavenged from peripheral tissues back to liver. The liver converts this cholesterol into bile acids, bile salts, and esterifies the rest and secretes them into bile. Low HDLc is a risk factor for atherogenesis. Higher levels of HDLc in plasma are therefore an index of safety from coronary heart disease and atherosclerosis. Regular physical exercise, and changes in life style like cessation of smoking, lowered alcohol consumption, modified dietary fat intake and certain medications can improve the level of HDLc in plasma.
高密度脂蛋白(HDL)在血浆中运输磷脂、胆固醇和三酰甘油。与HDL相关的胆固醇(HDLc)是从外周组织清除后返回肝脏的胆固醇。肝脏将这种胆固醇转化为胆汁酸、胆盐,并将其余部分酯化后分泌到胆汁中。HDLc水平低是动脉粥样硬化的一个危险因素。因此,血浆中较高水平的HDLc是预防冠心病和动脉粥样硬化的一个指标。定期体育锻炼以及生活方式的改变,如戒烟、减少饮酒、调整饮食脂肪摄入和某些药物治疗,都可以提高血浆中HDLc的水平。