Li Guanya, Chang Ling, Zhang Guanglei, Song Zehe, Wan Dan, Xie Chunyan, Wang Hong, Fan Zhiyong
Hunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology and College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, China.
Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production, Changsha, 410125, China.
Anim Nutr. 2018 Sep;4(3):260-264. doi: 10.1016/j.aninu.2018.06.002. Epub 2018 Jul 6.
Dibutyryl adenosine cyclophosphate (dbcAMP-Ca), an analog of cyclic adenosine monophosphate (cAMP), plays greater roles in regulating physiological activities and energy metabolism than cAMP. The aim of this study was to investigate the effect of oral administration of dbcAMP-Ca on growth performance and fatty acids metabolism in weaning piglets. A total of 14 early weaning piglets (7 ± 1 d of age, 3.31 ± 0.09 kg, Landrace × Large White × Duroc) were randomly divided into 2 groups: control group and dbcAMP-Ca group, and the piglets received 7 mL of 0.9% NaCl or 1.5 mg dbcAMP-Ca dissolved in 7 mL of 0.9% NaCl per day for 10 d, respectively. The results showed that the average daily gain (ADG) increased by 109.17% ( < 0.05) in the dbcAMP-Ca group compared with the control group. Besides, dbcAMP-Ca significantly decreased blood high density lipoprotein cholesterol (HDLC) concentration ( < 0.05) and significantly increased blood low density lipoprotein cholesterol (LDLC) concentration ( ＜ 0.05) compared with the control group. Further, liver C18:2n6t content significantly increased in dbcAMP-Ca group ( < 0.05) compared with the control group. With the increase of C18:2n6t content, the mRNA expression levels of peroxisome proliferator-activated receptor α () and hormone sensitive glycerol three lipase (), of which genes are related to lipid metabolism, were also significantly increased ( < 0.05 or < 0.01). All of the results indicated that dbcAMP-Ca improved the ADG, which was probably done by regulating fatty acids metabolism in the liver of weaning piglets.
二丁酰环磷腺苷钙（dbcAMP-Ca）是环磷酸腺苷（cAMP）的类似物，在调节生理活动和能量代谢方面比cAMP发挥着更重要的作用。本研究旨在探讨口服dbcAMP-Ca对断奶仔猪生长性能和脂肪酸代谢的影响。选取14头早期断奶仔猪（7±1日龄，体重3.31±0.09 kg，长白×大白×杜洛克），随机分为2组：对照组和dbcAMP-Ca组，仔猪分别每天灌服7 mL 0.9%氯化钠溶液或溶于7 mL 0.9%氯化钠溶液中的1.5 mg dbcAMP-Ca，持续10天。结果表明，与对照组相比，dbcAMP-Ca组的平均日增重（ADG）提高了109.17%（P<0.05）。此外，与对照组相比，dbcAMP-Ca显著降低了血液高密度脂蛋白胆固醇（HDLC）浓度（P<0.05），并显著提高了血液低密度脂蛋白胆固醇（LDLC）浓度（P＜0.05）。进一步研究发现，与对照组相比，dbcAMP-Ca组肝脏中C18:2n6t含量显著增加（P<0.05）。随着C18:2n6t含量的增加，与脂质代谢相关的过氧化物酶体增殖物激活受体α（PPARα）和激素敏感性甘油三酯脂肪酶（HSL）的mRNA表达水平也显著增加（P<0.05或P<0.01）。所有结果表明，dbcAMP-Ca提高了断奶仔猪的ADG，这可能是通过调节断奶仔猪肝脏中的脂肪酸代谢来实现的。
