通过自由基级联反应合成 Asperparaline 核心。
Synthesis of the asperparaline core by a radical cascade.
机构信息
School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
出版信息
Org Lett. 2011 Dec 16;13(24):6472-5. doi: 10.1021/ol202769f. Epub 2011 Nov 14.
PMID:22082317
Abstract
A concise access to the pentacyclic core structure of the asperparalines is described. The key step is a radical cascade sequence comprised of a 1,6-hydrogen atom transfer followed by 6-exo-trig and 5-exo-trig cyclizations.
摘要
本文描述了一种简洁的方法来构建 Asperparalines 的五环核心结构。关键步骤是一个由 1,6-氢原子转移引发的自由基级联序列，接着是 6-endo-trig 和 5-exo-trig 环化。
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