过氧化氢酶作为流感嗜血杆菌X因子和V因子的来源。

Catalase as a source of both X- and V-factor for Haemophilus influenzae.

作者信息

Morton Daniel J, VanWagoner Timothy M, Seale Thomas W, Whitby Paul W, Stull Terrence L

机构信息

Department of Pediatrics, University of Oklahoma Health Sciences Center, 940 NE 13th Street, Oklahoma City, OK 73104, USA.

出版信息

FEMS Microbiol Lett. 2008 Feb;279(2):157-61. doi: 10.1111/j.1574-6968.2007.01020.x. Epub 2007 Dec 18.

DOI:10.1111/j.1574-6968.2007.01020.x

PMID:18093136

Abstract

Haemophilus influenzae requires two growth factors, designated factor X (porphyrin) and factor V (NAD). Mammalian catalases contain both bound heme and NADPH. This study shows that catalase can supply both factors X and V to H. influenzae in vitro, thus representing a potential in vivo source of these essential growth factors.

摘要

流感嗜血杆菌需要两种生长因子，分别称为X因子（卟啉）和V因子（烟酰胺腺嘌呤二核苷酸）。哺乳动物过氧化氢酶既含有结合的血红素又含有烟酰胺腺嘌呤二核苷酸磷酸。本研究表明，过氧化氢酶在体外可同时为流感嗜血杆菌提供X因子和V因子，因此它可能是这些必需生长因子的体内来源。