Choonhakarn C, Busaracome P, Sripanidkulchai B, Sarakarn P
Division of Dermatology, Department of Medicine, Srinagarind Hospital Medical School, Faculty of Medicine, Khon Khaen University, Khon Kaen 40002, Thailand.
Br J Dermatol. 2008 Mar;158(3):573-7. doi: 10.1111/j.1365-2133.2007.08370.x. Epub 2007 Dec 17.
Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful especially in the atrophic and erosive forms. Several therapies have been tried, with varying results. There is one case report in which aloe vera (AV) was used successfully in the treatment of lichen planus.
To compare the efficacy of AV and placebo in the topical management of OLP.
A randomized, double-blind, placebo-controlled trial was designed. Fifty-four patients were randomized into two groups to receive AV gel or placebo for 8 weeks.
Fifty-four consecutive patients (34 women and 20 men) participated in the study. We found erosive and ulcerative lesions in 83% and 17%, respectively. The most common site of OLP was the lower lip. Twenty-two of 27 patients treated with AV (81%) had a good response after 8 weeks of treatment, while one of 27 placebo-treated patients (4%) had a similar response (P<0.001). Furthermore, two patients treated with AV (7%) had a complete clinical remission. Burning pain completely disappeared in nine patients treated with AV (33%) and in one treated with placebo (4%) (P=0.005). Symptomatology improved by at least 50% (good response) in 17 patients treated with AV (63%) and in two treated with placebo (7%) (P<0.001). No serious side-effects were found in both groups.
AV gel is statistically significantly more effective than placebo in inducing clinical and symptomatological improvement of OLP. Therefore, AV gel can be considered a safe alternative treatment for patients with OLP.
口腔扁平苔藓（OLP）是一种慢性炎症性疾病，尤其是萎缩性和糜烂性形式时会疼痛。已经尝试了几种治疗方法，结果各不相同。有一例报告成功使用芦荟（AV）治疗扁平苔藓。
比较AV和安慰剂在OLP局部治疗中的疗效。
设计了一项随机、双盲、安慰剂对照试验。54名患者被随机分为两组，接受AV凝胶或安慰剂治疗8周。
54名连续患者（34名女性和20名男性）参与了研究。我们分别在83%和17%的患者中发现了糜烂性和溃疡性病变。OLP最常见的部位是下唇。27名接受AV治疗的患者中有22名（81%）在治疗8周后有良好反应，而27名接受安慰剂治疗的患者中有1名（4%）有类似反应（P<0.001）。此外，两名接受AV治疗的患者（7%）实现了临床完全缓解。9名接受AV治疗的患者（33%）和1名接受安慰剂治疗的患者（4%）的灼痛完全消失（P=0.005）。17名接受AV治疗的患者（63%）和两名接受安慰剂治疗的患者（7%）的症状改善至少50%（良好反应）（P<0.001）。两组均未发现严重副作用。
在诱导OLP临床和症状改善方面，AV凝胶在统计学上比安慰剂显著更有效。因此，AV凝胶可被认为是OLP患者的一种安全替代治疗方法。
