Rados Jaka, Lipozencić Jasna, Celić Diana, Loncarić Davorin
University Department of Dermatology and Venereology, Zagreb University Hospital Center and School of Medicine, Salata 4, HR-10000 Zagreb, Croatia.
Acta Dermatovenerol Croat. 2007;15(4):249-53.
Löfgren's syndrome is an acute form of sarcoidosis that mostly presents with erythema nodosum, periarticular ankle inflammation, arthritis, conjunctivitis, and unilateral or bilateral hilar or right paratracheal lymphadenopathy. Erythema nodosum is the most common cutaneous lesion in acute sarcoidosis, but it is histologically nonspecific, as it does not reveal sarcoidal granulomas upon microscopic examination. We present a case of a 57-year-old woman with acute onset of tender erythematous nodules on the calves, which were clinically erythema nodosum-like lesions. Histologic analysis revealed sarcoidal granulomas located in the dermis and subcutaneous tissue. Upon further work-up, the patient was found to have both pulmonary and ocular sarcoidosis. Based on this case, we recommend that all patients with erythema nodosum-like lesions undergo biopsy and further work-up for sarcoidosis is recommended in case of biopsy proven sarcoidal granulomas.
Löfgren综合征是结节病的一种急性形式，主要表现为结节性红斑、踝关节周围炎症、关节炎、结膜炎以及单侧或双侧肺门或右气管旁淋巴结肿大。结节性红斑是急性结节病最常见的皮肤病变，但在组织学上不具有特异性，因为在显微镜检查时未发现结节病性肉芽肿。我们报告一例57岁女性，小腿出现急性起病的压痛性红斑结节，临床为结节性红斑样病变。组织学分析显示真皮和皮下组织中有结节病性肉芽肿。进一步检查发现该患者患有肺部和眼部结节病。基于此病例，我们建议所有患有结节性红斑样病变的患者均接受活检，若活检证实为结节病性肉芽肿，则建议对结节病进行进一步检查。
