Williams Stephen R, Wozny Christian, Mitchell Simon J
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.
Neuron. 2007 Dec 20;56(6):947-53. doi: 10.1016/j.neuron.2007.12.004.
Synapses are located throughout the often-elaborate dendritic tree of central neurons. Hebbian models of plasticity require temporal association between synaptic input and neuronal output to produce long-term potentiation of excitatory transmission. Recent studies have highlighted how active dendritic spiking mechanisms control this association. Here, we review new work showing that associative synaptic plasticity can be generated without neuronal output and that the interplay between neuronal architecture and the active electrical properties of the dendritic tree regulates synaptic plasticity.
突触遍布中枢神经元通常复杂的树突树。可塑性的赫布模型要求突触输入与神经元输出之间存在时间关联，以产生兴奋性传递的长期增强。最近的研究突出了活跃的树突棘机制如何控制这种关联。在这里，我们回顾新的研究工作，这些工作表明可以在没有神经元输出的情况下产生联合突触可塑性，并且神经元结构与树突树的活跃电特性之间的相互作用调节突触可塑性。
