自闭症儿童母亲血清中针对胎儿大脑的抗体。
Antibodies against fetal brain in sera of mothers with autistic children.
作者信息
Singer Harvey S, Morris Christina M, Gause Colin D, Gillin Pam K, Crawford Stephen, Zimmerman Andrew W
机构信息
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States.
出版信息
J Neuroimmunol. 2008 Feb;194(1-2):165-72. doi: 10.1016/j.jneuroim.2007.11.004. Epub 2008 Feb 21.
Serum antibodies in 100 mothers of children with autistic disorder (MCAD) were compared to 100 age-matched mothers with unaffected children (MUC) using as antigenic substrates human and rodent fetal and adult brain tissues, GFAP, and MBP. MCAD had significantly more individuals with Western immunoblot bands at 36 kDa in human fetal and rodent embryonic brain tissue. The density of bands was greater in fetal brain at 61 kDa. MCAD plus developmental regression had greater reactivity against human fetal brain at 36 and 39 kDa. Data support a possible complex association between genetic/metabolic/environmental factors and the placental transfer of maternal antibodies in autism.
将100名自闭症谱系障碍儿童的母亲（MCAD）的血清抗体与100名年龄匹配的子女未受影响的母亲（MUC）的血清抗体进行了比较，使用人和啮齿动物的胎儿及成人脑组织、胶质纤维酸性蛋白（GFAP）和髓鞘碱性蛋白（MBP）作为抗原底物。在人胎儿和啮齿动物胚胎脑组织中，MCAD中在36 kDa处出现Western免疫印迹条带的个体显著更多。在61 kDa处，胎儿脑组织中的条带密度更大。伴有发育倒退的MCAD对人胎儿脑在36 kDa和39 kDa处具有更高的反应性。数据支持了遗传/代谢/环境因素与自闭症中母体抗体的胎盘转运之间可能存在复杂关联。
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