自闭症儿童及其未受影响的兄弟姐妹体内的抗脑抗体。
Antibrain antibodies in children with autism and their unaffected siblings.
作者信息
Singer Harvey S, Morris Christina M, Williams Phillip N, Yoon Dustin Y, Hong John J, Zimmerman Andrew W
机构信息
Department of Neurology, Johns Hopkins University School of Medicine, Jefferson Street Building 124, 600 N. Wolfe Street, Baltimore, MD 21287-1000, USA.
出版信息
J Neuroimmunol. 2006 Sep;178(1-2):149-55. doi: 10.1016/j.jneuroim.2006.05.025. Epub 2006 Jul 13.
Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p<0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p<0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.
通过酶联免疫吸附测定（ELISA）和蛋白质免疫印迹法鉴定出的针对人脑的血清自身抗体，在29名自闭症谱系障碍儿童（22名患有自闭症）、9名非自闭症兄弟姐妹和13名对照中进行了评估。与对照组相比，更多自闭症受试者在尾状核、壳核和前额叶皮质中出现了100 kDa的条带（p<0.01），并且在小脑和扣带回中73 kDa条带的峰高更大。自闭症障碍受试者及其匹配的非自闭症兄弟姐妹在小脑和扣带回中73 kDa的条带（峰高和/或曲线下面积）比对照组更密集（p<0.01）。结果表明，与对照组相比，患有自闭症障碍的儿童及其兄弟姐妹在对位于不同脑区的特定表位的自身免疫反应性方面存在差异。
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