Li Sheng-Jiao, Guo Wei, Ren Guo-Xin, Huang Gang, Chen Tao, Song Shao-Li
Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, P. R. China.
Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Research Institute of Stomatology, Shanghai, P. R. China.
Br J Oral Maxillofac Surg. 2008 Apr;46(3):180-186. doi: 10.1016/j.bjoms.2007.11.003. Epub 2008 Feb 21.
The aim of the study was to investigate the pattern of glucose transporter-1 (Glut-1) expression in primary and recurrent head and neck squamous cell carcinomas (HNSCCAs) and the relation between Glut-1 expression and 2-[18F]fluoro-2-deoxy-D-glucose - positron emission tomography (FDG-PET). Standardised uptake values (SUVs) were used to evaluate FDG uptake by the tumour. Sections were stained immunohistochemically for Glut-1, which showed that high SUVs were seen in all HNSCCAs, and patients with higher T stage tumours or less well-differentiated tumours showed significantly higher SUVs than those with lower stage tumours or better-differentiated tumours (P=0.001 and 0.04, respectively). Glut-1 immunostaining was present in all cases. The Glut-1 staining index in primary HNSCCAs was significantly lower than that in recurrent HNSCCAs (P=0.03), and the index of better-differentiated tumours lower than that of poorly-differentiated tumours (P=0.02). However, there was no significant correlation between SUV(mean) and the Glut-1 staining index. In conclusion, our data suggest that high FDG uptakes were seen with overexpression of Glut-1 in primary and recurrent HNSCCAs. SUV(mean) was related to tumour T stage and grade of differentiation, which indicated that SUV was helpful in evaluating tumours. The expression of Glut-1 in recurrent HNSCCAs was higher than that in primary HNSCCAs, and in poorly-differentiated HNSCCAs higher than in better-differentiated HNSCCAs, which indicated that Glut-1 may have a useful role as a predictor for poor prognosis in HNSCCAs. However, there was no significant correlation between FDG accumulation and Glut-1 expression.
本研究的目的是调查原发性和复发性头颈部鳞状细胞癌（HNSCCA）中葡萄糖转运蛋白1（Glut-1）的表达模式，以及Glut-1表达与2-[18F]氟-2-脱氧-D-葡萄糖-正电子发射断层扫描（FDG-PET）之间的关系。使用标准化摄取值（SUV）评估肿瘤对FDG的摄取。对切片进行Glut-1免疫组织化学染色，结果显示所有HNSCCA中均可见高SUV值，T分期较高或分化较差的肿瘤患者的SUV值显著高于T分期较低或分化较好的肿瘤患者（P分别为0.001和0.04）。所有病例均存在Glut-1免疫染色。原发性HNSCCA中的Glut-1染色指数显著低于复发性HNSCCA（P=0.03），分化较好的肿瘤的指数低于分化较差的肿瘤（P=0.02）。然而，SUV（平均值）与Glut-1染色指数之间无显著相关性。总之，我们的数据表明，在原发性和复发性HNSCCA中，Glut-1过表达时可见高FDG摄取。SUV（平均值）与肿瘤T分期和分化程度相关，这表明SUV有助于评估肿瘤。复发性HNSCCA中Glut-1的表达高于原发性HNSCCA，在分化较差的HNSCCA中高于分化较好的HNSCCA，这表明Glut-1可能作为HNSCCA预后不良的预测指标具有重要作用。然而，FDG积聚与Glut-1表达之间无显著相关性。
