Surov Alexey, Meyer Hans Jonas, Höhn Anne-Kathrin, Wienke Andreas, Sabri Osama, Purz Sandra
Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
Department of Pathology, University Hospital of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
Cancers (Basel). 2019 Apr 15;11(4):543. doi: 10.3390/cancers11040543.
: Positron emission tomography (PET) with F-fluordeoxyglucose (F-FDG) plays an essential role in the staging and tumor monitoring of head and neck squamous cell carcinoma (HNSCC). Microvessel density (MVD) is one of the clinically important histopathological features in HNSCC. The purpose of this study was to analyze possible associations between F-FDG-PET findings and MVD parameters in HNSCC. : Overall, 22 patients with a mean age of 55.2 ± 11.0 and with different HNSCC were acquired. In all cases, whole-body F-FDG-PET was performed. For each tumor, the maximum and mean standardized uptake values (SUV; SUV) were determined. The MVD, including stained vessel area and total number of vessels, was estimated on CD105 stained specimens. All specimens were digitalized and analyzed by using ImageJ software 1.48v. Spearman's correlation coefficient () was used to analyze associations between investigated parameters. -values of <0.05 were taken to indicate statistical significance. SUV correlated with vessel area ( = 0.532, = 0.011) and vessel count ( = 0.434, = 0.043). Receiver operating characteristic analysis identified a threshold SUV of 15 to predict tumors with high MVD with a sensitivity of 72.7% and specificity of 81.8%, with an area under the curve of 82.6%. ⁸F-FDG-PET parameters correlate statistically significantly with MVD in HNSCC. SUV may be used for discrimination of tumors with high tumor-related MVD.
氟代脱氧葡萄糖（F-FDG）正电子发射断层扫描（PET）在头颈部鳞状细胞癌（HNSCC）的分期和肿瘤监测中起着至关重要的作用。微血管密度（MVD）是HNSCC重要的临床组织病理学特征之一。本研究旨在分析HNSCC中F-FDG-PET检查结果与MVD参数之间可能存在的关联。总体而言，纳入了22例平均年龄为55.2±11.0岁、患有不同类型HNSCC的患者。所有病例均进行了全身F-FDG-PET检查。对于每个肿瘤，测定其最大和平均标准化摄取值（SUV）。在CD105染色的标本上估计MVD，包括染色血管面积和血管总数。所有标本均进行数字化处理，并使用ImageJ软件1.48v进行分析。采用Spearman相关系数（）分析所研究参数之间的关联。P值<0.05表示具有统计学意义。SUV与血管面积（=0.532，P=0.011）和血管计数（=0.434，P=0.043）相关。受试者工作特征分析确定SUV阈值为15可预测高MVD肿瘤，灵敏度为72.7%，特异性为81.8%，曲线下面积为82.6%。⁸F-FDG-PET参数与HNSCC中的MVD在统计学上显著相关。SUV可用于鉴别具有高肿瘤相关MVD的肿瘤。
