Toussaint D, Vereerstraeten P, Goffin P, Vanlanduyt P, Jedwab J, Legrand J M
Arch Ophtalmol (Paris). 1976 Feb;36(2):97-112.
A post-mortem histological examination of the eyes of a case of primary hyperoxaluria revealed the presence of crystals in the ciliary processes and at the level of the retinal pigment epithelium. The crystallography study demonstrated that it consisted of wewhellite. The ocular lesions are compared with those found by other authors in primary hyperoxaluria, after prolonged methoxyflurane anaesthesia, after experimental administration of dibutyloxalic acid or naphthalene, and in the human retina in longstanding detachments. Most of the factors which give rise to the presence in the eye of oxalate and its selective precipitation in the midst of certain ocular tissues remain hypothetical. The retinal lesions observed in primary hyperoxaluria appear to be pathognomonic for hyperoxalaemia.
对一例原发性高草酸尿症患者眼睛进行的尸检组织学检查显示，睫状体和视网膜色素上皮层存在晶体。晶体学研究表明其成分为水草酸钙石。将这些眼部病变与其他作者在原发性高草酸尿症患者长期使用甲氧氟烷麻醉后、实验性给予二丁基草酸或萘后以及人类视网膜长期脱离时所发现的病变进行了比较。导致眼部存在草酸盐并在某些眼部组织中选择性沉淀的大多数因素仍属假设。原发性高草酸尿症中观察到的视网膜病变似乎是高草酸血症的特征性表现。
