Penn Raymond B, Benovic Jeffrey L
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA.
Proc Am Thorac Soc. 2008 Jan 1;5(1):47-57. doi: 10.1513/pats.200705-054VS.
Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.
异源三聚体G蛋白转导来自G蛋白偶联受体的信号，以调节气道平滑肌（ASM）中的众多信号事件和功能。在本文中，我们详细阐述了异源三聚体G蛋白信号在ASM中的功能和调节。我们还讨论了G蛋白信号研究中实验工具开发的最新进展，并推测这些工具如何用于旨在减轻阻塞性气道疾病中发生的支气管痉挛和气道重塑的治疗策略。
