通过多种方式引导放松：TMEM16A拮抗剂治疗哮喘 - Suppr

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超能文献

Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.

作者信息

Jannu Arun K, Penn Raymond B

机构信息

Center for Translational Medicine Thomas Jefferson University Philadelphia, Pennsylvania.

出版信息

Am J Respir Cell Mol Biol. 2025 May;72(5):466-468. doi: 10.1165/rcmb.2024-0521ED.

DOI:10.1165/rcmb.2024-0521ED

PMID:39589219

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12051912/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2119/12051912/d3fa78249437/rcmb.2024-0521EDf1.jpg

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本文引用的文献

TMEM16A Antagonism: Therapeutic Potential with Desensitization of β-Agonist Responsiveness in Asthma.跨膜蛋白16A（TMEM16A）拮抗作用：对哮喘中β-激动剂反应性脱敏的治疗潜力

Am J Respir Cell Mol Biol. 2025 May;72(5):510-519. doi: 10.1165/rcmb.2024-0231OC.

Identification of a β-arrestin-biased negative allosteric modulator for the β-adrenergic receptor.β-肾上腺素能受体的β-arrestin 偏向性负变构调节剂的鉴定。

Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2302668120. doi: 10.1073/pnas.2302668120. Epub 2023 Jul 25.

In silico identification of a β-adrenoceptor allosteric site that selectively augments canonical βAR-Gs signaling and function.通过计算机筛选出一种β-肾上腺素能受体变构位点，该位点选择性增强经典βAR-Gs 信号转导和功能。

Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2214024119. doi: 10.1073/pnas.2214024119. Epub 2022 Nov 30.

The pharmacology of the TMEM16A channel: therapeutic opportunities.TMEM16A 通道的药理学：治疗机会。

Trends Pharmacol Sci. 2022 Sep;43(9):712-725. doi: 10.1016/j.tips.2022.06.006. Epub 2022 Jul 7.

Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone.TMEM16A 钙激活氯离子通道激动剂调节气道平滑肌张力。

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L287-L295. doi: 10.1152/ajplung.00552.2018. Epub 2019 Nov 20.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.药物再利用：驱虫药氯硝柳胺和硝唑尼特是强效的TMEM16A拮抗剂，可使气道完全舒张。

Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019.

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM.冷冻电镜解析钙激活氯离子通道 TMEM16A 的激活机制。

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Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.钙激活氯离子通道TMEM16A中阴离子传导的结构基础。

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GPCRs and arrestins in airways: implications for asthma.气道中的G蛋白偶联受体与抑制蛋白：对哮喘的影响

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