Tliba Omar, Amrani Yassine
Pulmonary, Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, PA, USA.
Proc Am Thorac Soc. 2008 Jan 1;5(1):106-12. doi: 10.1513/pats.200705-060VS.
The present article will describe the potential role of airway smooth muscle (ASM) in mediating both deleterious/beneficial effects of interferons (IFNs) in asthma. First described as beneficial in treating the main features of asthma, the interplay between IFNs and ASM could explain their deleterious actions recently described in a number of different studies. Through multiple mechanisms, including the suppression of steroid action, the synergistic pro-inflammatory actions when combined with other cytokines, and the modulation of calcium metabolism, IFNs are now seen as critical mediators in the pathogenesis of asthma.
本文将描述气道平滑肌（ASM）在介导干扰素（IFN）对哮喘的有害/有益作用中可能发挥的作用。IFN最初被认为对治疗哮喘的主要症状有益，但其与ASM之间的相互作用或许可以解释最近在多项不同研究中所描述的有害作用。通过多种机制，包括抑制类固醇作用、与其他细胞因子联合时的协同促炎作用以及对钙代谢的调节，IFN现在被视为哮喘发病机制中的关键介质。
