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Obesity impacts access to kidney transplantation.肥胖影响肾移植的可及性。
J Am Soc Nephrol. 2008 Feb;19(2):349-55. doi: 10.1681/ASN.2007050610. Epub 2007 Dec 19.
2
Prolonged waiting times for liver transplantation in obese patients.肥胖患者肝移植等待时间延长。
Ann Surg. 2008 Nov;248(5):863-70. doi: 10.1097/SLA.0b013e31818a01ef.
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Differential association of body mass index with access to kidney transplantation in men and women.体重指数与男性和女性肾移植可及性的差异关联。
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Morbid obesity is not an independent predictor of graft failure or patient mortality after kidney transplantation.病态肥胖不是肾移植后移植物失败或患者死亡的独立预测因子。
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Obesity and gender-biased access to deceased donor kidney transplantation.肥胖与性别偏见对接受已故供体肾移植的影响。
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Morbid obesity is not a contraindication to kidney transplantation.病态肥胖并非肾移植的禁忌证。
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Higher Mortality and Survival Benefit in Obese Patients Awaiting Liver Transplantation.等待肝移植的肥胖患者死亡率更高且生存获益情况
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Access to kidney transplantation among remote- and rural-dwelling patients with kidney failure in the United States.美国偏远和农村地区肾衰竭患者获得肾脏移植的情况。
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Combined Body Mass Index and Body Surface Area to Predict Post Kidney Transplant Outcomes in Patients With Obesity.联合体重指数和体表面积预测肥胖患者肾移植术后结局
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The Case for Trauma-Informed Chronic Disease Care: Exploring Trauma Among Adults With Obesity On Dialysis.创伤知情的慢性病护理案例:探索接受透析的肥胖成年人中的创伤情况。
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Identifying when racial and ethnic disparities arise along the continuum of transplant care: a national registry study.确定种族和族裔差异在移植护理连续过程中何时出现:一项全国登记研究。
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Evaluating the safety of bariatric surgery as a bridge to kidney transplant: a retrospective cohort study.评估减肥手术作为肾移植桥接的安全性:一项回顾性队列研究。
Surg Endosc. 2024 Oct;38(10):5980-5991. doi: 10.1007/s00464-024-11087-0. Epub 2024 Jul 31.

本文引用的文献

1
Risk factors for development of new-onset diabetes mellitus after kidney transplantation.肾移植后新发糖尿病的危险因素
Transplantation. 2006 Dec 27;82(12):1673-6. doi: 10.1097/01.tp.0000250756.66348.9a.
2
A "weight-listing" paradox for candidates of renal transplantation?肾移植候选者的“体重清单”悖论?
Am J Transplant. 2007 Mar;7(3):550-9. doi: 10.1111/j.1600-6143.2006.01629.x. Epub 2006 Dec 6.
3
New-onset diabetes after kidney transplantation: risk factors.肾移植后新发糖尿病:危险因素
J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S291-5. doi: 10.1681/ASN.2006080929.
4
The influence of obesity on short- and long-term graft and patient survival after renal transplantation.肥胖对肾移植后短期和长期移植物及患者生存的影响。
Transpl Int. 2006 Nov;19(11):901-7. doi: 10.1111/j.1432-2277.2006.00367.x.
5
Body mass index as a predictive factor for long-term renal transplant outcomes in Asians.体重指数作为亚洲人长期肾移植预后的预测因素。
Clin Transplant. 2006 Sep-Oct;20(5):582-9. doi: 10.1111/j.1399-0012.2006.00520.x.
6
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies.体重与冠状动脉疾病的全因死亡率及心血管事件的关联:队列研究的系统评价
Lancet. 2006 Aug 19;368(9536):666-78. doi: 10.1016/S0140-6736(06)69251-9.
7
Obesity and infection.肥胖与感染
Lancet Infect Dis. 2006 Jul;6(7):438-46. doi: 10.1016/S1473-3099(06)70523-0.
8
Prevalence of overweight and obesity in the United States, 1999-2004.1999 - 2004年美国超重和肥胖的患病率
JAMA. 2006 Apr 5;295(13):1549-55. doi: 10.1001/jama.295.13.1549.
9
Obesity and outcome following renal transplantation.肾移植后的肥胖与预后
Am J Transplant. 2006 Feb;6(2):357-63. doi: 10.1111/j.1600-6143.2005.01198.x.
10
High body mass index and short- and long-term renal allograft survival in adults.成人高体重指数与肾移植短期和长期存活情况
Transplantation. 2005 Nov 27;80(10):1430-4. doi: 10.1097/01.tp.0000181094.68259.88.

肥胖影响肾移植的可及性。

Obesity impacts access to kidney transplantation.

作者信息

Segev Dorry L, Simpkins Christopher E, Thompson Richard E, Locke Jayme E, Warren Daniel S, Montgomery Robert A

机构信息

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

出版信息

J Am Soc Nephrol. 2008 Feb;19(2):349-55. doi: 10.1681/ASN.2007050610. Epub 2007 Dec 19.

DOI:10.1681/ASN.2007050610
PMID:18094366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2396750/
Abstract

Current billing practices and mandates to report surgical outcomes are disincentives to surgical treatment of obese patients, who are at increased risk for longer hospital stays and higher complication rates. The objective of this study was to quantify the independent association between body mass index (BMI) and waiting time for kidney transplantation to identify potential provider bias against surgical treatment of the obese. A secondary data analysis was performed of a prospective cohort of 132,353 patients who were registered for kidney transplantation in the United States between 1995 and 2006. Among all patients awaiting kidney transplantation, the likelihood of receiving a transplant decreased with increasing degree of obesity, categorized by ranges of BMI (adjusted hazard ratios 0.96 for overweight, 0.93 for obese, 0.72 for severely obese, and 0.56 for morbidly obese, compared with a reference group of patients with normal BMI). Similarly, the likelihood of being bypassed when an organ became available increased in a graded manner with category of obesity (adjusted incidence rate ratio 1.02 for overweight, 1.05 for obese, 1.11 for severely obese, and 1.22 for morbidly obese). Although matching an available organ with an appropriate recipient requires clinical judgment, which could not be fully captured in this study, the observed differences are dramatic and warrant further studies to understand this effect better and to design a system that is less susceptible to unintended bias.

摘要

当前的计费方式以及报告手术结果的要求不利于肥胖患者接受手术治疗,因为这类患者住院时间更长、并发症发生率更高。本研究的目的是量化体重指数(BMI)与肾移植等待时间之间的独立关联,以确定医疗服务提供者对肥胖患者手术治疗可能存在的偏见。对1995年至2006年间在美国登记等待肾移植的132353名患者的前瞻性队列进行了二次数据分析。在所有等待肾移植的患者中,接受移植的可能性随着肥胖程度的增加而降低,肥胖程度按BMI范围分类(与BMI正常的参考组相比,超重患者的调整风险比为0.96,肥胖患者为0.93,重度肥胖患者为0.72,病态肥胖患者为0.56)。同样,当有可用器官时被跳过的可能性随着肥胖类别呈分级增加(超重患者的调整发病率比为1.02,肥胖患者为1.05,重度肥胖患者为1.11,病态肥胖患者为1.22)。尽管将可用器官与合适的受者进行匹配需要临床判断,而本研究无法完全体现这一点,但观察到的差异非常显著,值得进一步研究以更好地理解这种影响,并设计一个不易受到意外偏见影响的系统。