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肥胖影响肾移植的可及性。

Obesity impacts access to kidney transplantation.

作者信息

Segev Dorry L, Simpkins Christopher E, Thompson Richard E, Locke Jayme E, Warren Daniel S, Montgomery Robert A

机构信息

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

出版信息

J Am Soc Nephrol. 2008 Feb;19(2):349-55. doi: 10.1681/ASN.2007050610. Epub 2007 Dec 19.

Abstract

Current billing practices and mandates to report surgical outcomes are disincentives to surgical treatment of obese patients, who are at increased risk for longer hospital stays and higher complication rates. The objective of this study was to quantify the independent association between body mass index (BMI) and waiting time for kidney transplantation to identify potential provider bias against surgical treatment of the obese. A secondary data analysis was performed of a prospective cohort of 132,353 patients who were registered for kidney transplantation in the United States between 1995 and 2006. Among all patients awaiting kidney transplantation, the likelihood of receiving a transplant decreased with increasing degree of obesity, categorized by ranges of BMI (adjusted hazard ratios 0.96 for overweight, 0.93 for obese, 0.72 for severely obese, and 0.56 for morbidly obese, compared with a reference group of patients with normal BMI). Similarly, the likelihood of being bypassed when an organ became available increased in a graded manner with category of obesity (adjusted incidence rate ratio 1.02 for overweight, 1.05 for obese, 1.11 for severely obese, and 1.22 for morbidly obese). Although matching an available organ with an appropriate recipient requires clinical judgment, which could not be fully captured in this study, the observed differences are dramatic and warrant further studies to understand this effect better and to design a system that is less susceptible to unintended bias.

摘要

当前的计费方式以及报告手术结果的要求不利于肥胖患者接受手术治疗,因为这类患者住院时间更长、并发症发生率更高。本研究的目的是量化体重指数(BMI)与肾移植等待时间之间的独立关联,以确定医疗服务提供者对肥胖患者手术治疗可能存在的偏见。对1995年至2006年间在美国登记等待肾移植的132353名患者的前瞻性队列进行了二次数据分析。在所有等待肾移植的患者中,接受移植的可能性随着肥胖程度的增加而降低,肥胖程度按BMI范围分类(与BMI正常的参考组相比,超重患者的调整风险比为0.96,肥胖患者为0.93,重度肥胖患者为0.72,病态肥胖患者为0.56)。同样,当有可用器官时被跳过的可能性随着肥胖类别呈分级增加(超重患者的调整发病率比为1.02,肥胖患者为1.05,重度肥胖患者为1.11,病态肥胖患者为1.22)。尽管将可用器官与合适的受者进行匹配需要临床判断,而本研究无法完全体现这一点,但观察到的差异非常显著,值得进一步研究以更好地理解这种影响,并设计一个不易受到意外偏见影响的系统。

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Obesity impacts access to kidney transplantation.肥胖影响肾移植的可及性。
J Am Soc Nephrol. 2008 Feb;19(2):349-55. doi: 10.1681/ASN.2007050610. Epub 2007 Dec 19.

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