Koate P
Bull Acad Natl Med. 1991 Oct;175(7):1055-62; discussion 1062-3.
The author, in the light of 14 cardiovascular pathology cases among patients affected by sickle cell disease, itemizes the following data: Cardiovascular pathology in sickle cell disease can be a preoccupation not only among homozygotes but also among heterozygotes. The clinical polymorphism of this pathology concern not only the common anemia heart disease and the type of sickle cell heart disease what looks like a rheumatic heart disease, but also includes cases of cor pulmonale among young patients, sickle cell cardiomyopathy, and myocardial infarction among young. The sickle cell disease area, which outstrips the borders of the traditional african "sickle cell belt" requires that all practitioners be widely informed of the sometimes disconcerting polymorphism of this cardiovascular pathology which has a fairly particular etiology.
作者根据镰状细胞病患者中的14例心血管病理病例，列出了以下数据：镰状细胞病中的心血管病理不仅在纯合子中，而且在杂合子中都可能是一个令人担忧的问题。这种病理的临床多态性不仅涉及常见的贫血性心脏病和类似风湿性心脏病的镰状细胞性心脏病类型，还包括年轻患者中的肺心病病例、镰状细胞性心肌病以及年轻人中的心肌梗死。镰状细胞病的发病区域超出了传统非洲“镰状细胞带”的边界，这就要求所有从业者广泛了解这种心血管病理有时令人不安的多态性，其病因相当特殊。
