Miguita Karen, Cordeiro Quirino, Siqueira-Roberto Jacqueline, Shavitt Roseli Gedanke, Castillo José Carlos Ramos, Castillo Ana Regina, Miguel Euripedes Constantino, Vallada Homero
Department and Institute of Psychiatry Progene LIM-23, University of São Paulo Medical School, São Paulo, SP, Brazil.
Arq Neuropsiquiatr. 2007 Dec;65(4A):936-41. doi: 10.1590/s0004-282x2007000600002.
Family, twin and segregation analysis have provided evidences that genetic factors are implicated in the susceptibility for obsessive-compulsive disorder (OCD). Several lines of research suggest that the dopaminergic system may be involved in the pathophysiology of OCD. Thus, the aim of the present study was to investigate a possible association between a polymorphism located in intron 8 of the dopamine transporter gene (SLC6A3) and OCD in a Brazilian sample composed by 208 patients and 865 healthy controls. No statistical differences were observed in allelic and genotype distributions between cases and controls. No association was also observed when the sample was divided according to specific phenotypic features such as gender, presence of tic disorders, co-morbidity, and age at onset of obsessive-compulsive symptoms (OCS). Our results suggest that the intron 8 VNTR of the SLC6A3 investigated in this study is not related to the susceptibility for OCD in our Brazilian sample.
家系、双生子和分离分析已提供证据表明，遗传因素与强迫症（OCD）易感性有关。多项研究表明，多巴胺能系统可能参与强迫症的病理生理过程。因此，本研究的目的是在一个由208例患者和865名健康对照组成的巴西样本中，研究多巴胺转运体基因（SLC6A3）第8内含子中的一个多态性与强迫症之间可能存在的关联。病例组和对照组在等位基因和基因型分布上未观察到统计学差异。当根据特定表型特征（如性别、抽动障碍的存在、共病情况以及强迫症状（OCS）的发病年龄）对样本进行划分时，也未观察到关联。我们的结果表明，本研究中所研究的SLC6A3第8内含子可变数目串联重复序列（VNTR）与我们巴西样本中强迫症的易感性无关。
